The acute effects of amitriptyline, iprindole and trazodone on blood pressure and heart rate in rats

Richardson, Jeremy; Chiu, Edward K.Y.

doi:10.1016/0091-3057(82)90124-1

Cited by 5 publications

(4 citation statements)

References 8 publications

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“…In consistent with these findings, the present study shows that vascular H + -ATPase contributes to increased blood pressure in AngII-induced hypertensive rats. In addition, the finding that amitriptyline decreased SBP in AngII-induced hypertension in the present study is consistent with previous studies showing that prolonged amitriptyline treatment decreased arterial blood Chiu, 1982).…”

Section: Discussionsupporting

confidence: 93%

Membrane raft redox signalling contributes to endothelial dysfunction and vascular remodelling of thoracic aorta in angiotensin II‐infused rats

Wei

et al. 2019

Experimental Physiology

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New Findings What is the central question of this study?Is the membrane raft redox signalling pathway involved in blood pressure increase, endothelial dysfunction and vascular remodelling in an angiotensin II‐induced hypertensive animal model? What is the main finding and its importance?The membrane raft redox signalling pathway was involved in endothelial dysfunction and medial remodelling in angiotensin II‐induced hypertension. Abstract The membrane raft (MR) redox pathway is characterized by NADPH oxidase activation via the clustering of its subunits through lysosome fusion and the activation of acid sphingomyelinase (ASMase). Our previous study shows that the MR redox signalling pathway is associated with angiontensin II (AngII)‐induced production of reactive oxygen species (ROS) and endothelial dysfunction in rat mesenteric arteries. In the present study, we hypothesized that this signalling pathway is involved in blood pressure increase, endothelial dysfunction and vascular remodelling in an AngII‐induced hypertensive animal model. Sixteen‐week‐old male Sprague–Dawley rats were subjected to AngII infusion for 2 weeks with or without treatment with the lysosome fusion inhibitor bafilomycin A1 and ASMase inhibitor amitriptyline. After treatments, aortas were harvested for further study. The results showed that the MR redox signalling pathway was activated as indicated by the increase of MR formation, ASMase activity and ROS production in aorta from AngII‐infused rats compared with that from control rats. MR formation and ROS production were significantly inhibited in thoracic aorta from AngII‐induced rats treated with bafilomycin A1 and amitriptyline. Both treatments significantly attenuated blood pressure increase, endothelial dysfunction and vascular remodelling including medial hypertrophy, and increased collagen and fibronectin deposition in thoracic aortas from AngII‐infused rats. Finally, both treatments significantly prevented the increase of inflammatory factors including monocyte chemotactic protein 1, intercellular adhesion molecule 1 and tumour necrosis factor α in thoracic aorta from AngII‐infused rats. In conclusion, the present study demonstrates that the MR redox signalling pathway was involved in endothelial dysfunction and medial remodelling in AngII‐induced hypertension.

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Section: Discussionsupporting

confidence: 93%

Membrane raft redox signalling contributes to endothelial dysfunction and vascular remodelling of thoracic aorta in angiotensin II‐infused rats

Wei

et al. 2019

Experimental Physiology

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“…However, studies by Richardson and Chiu have shown that AMI, given icv at a high dose (0.25 mg), evokes the hypotensive effect in anaesthetised rats, which is probably related to the inhibition of noradrenaline re-uptake and its action in the anterior hypothalamus [8]. Therefore, we conclude that amitriptyline affects the reactivity of the cardiovascular centre to hypotensive stimuli and infl uences central histamineinduced resuscitating effect.…”

Section: Resultsmentioning

confidence: 87%

Influence of amitriptyline on central histamine-induced reversal of haemorrhagic shock in rats

2007

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“…These findings are consistent with nonselective c~ atagonism. Specific a2 receptor blockade is suggested by studies in which TRZ caused hypotension and bradycardia when injected into the lateral cerebral ventricle of rats (Richardson and Chiu 1982), and blocked the hypotensive effect of clonidine when injected into the vertebral artery of cats (van Zwieten 1977). Blockade of presynaptic a2 autoreceptors is suggested by the slight activation of locus coeruleus firing rate noted on injection of TRZ into the jugular vein of rats (ScuveeMoreau and Dresse 1982).…”

Section: Discussionmentioning

confidence: 99%

“…TRZ shows weak affinity for ~2 and//adrenoceptors, but strong affinity for cq receptors (Maggi et al 1980;Clements-Jewery et al 1980;Riblet and Taylor 1981;Enna and Kendall 1981). Given acutely to animals, TRZ has antagonist effects in models of c~2 (van Zwieten 1977;Richardson and Chiu 1982;ScuveeMoreau and Dresse 1982) and nonselective e (Tempesta et al 1984) adrenoceptor function. Nonselective 0~ antagonism also occurs on acute administration in humans (Larochelle et al 1979;Rowbotham et al 1984).…”

mentioning

confidence: 99%

Effects of trazodone treatment on alpha-2 adrenoceptor function in depressed patients

1986

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Tricyclic antidepressant drugs reduce the sensitivity of alpha 2 adrenoceptors during long-term treatment. In the present study, the alpha 2 adrenergic agonist clonidine was administered to 11 depressed patients before and during treatment with the triazolopyridine antidepressant trazodone (TRZ). Clonidine's ability to decrease blood pressure (BP) and plasma levels of the norepinephrine metabolite 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG), and to increase sedation and plasma growth hormone (GH), were measured. TRZ had little effect on these indices of pre- and postsynaptic alpha 2 receptor function, suggesting that the antidepressant properties of TRZ are not related to changes in alpha 2 adrenoceptor sensitivity.

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The acute effects of amitriptyline, iprindole and trazodone on blood pressure and heart rate in rats

Cited by 5 publications

References 8 publications

Membrane raft redox signalling contributes to endothelial dysfunction and vascular remodelling of thoracic aorta in angiotensin II‐infused rats

Membrane raft redox signalling contributes to endothelial dysfunction and vascular remodelling of thoracic aorta in angiotensin II‐infused rats

Influence of amitriptyline on central histamine-induced reversal of haemorrhagic shock in rats

Effects of trazodone treatment on alpha-2 adrenoceptor function in depressed patients

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