The acute effects of cannabidiol on emotional processing and anxiety: a neurocognitive imaging study

Abstract

BackgroundThere is growing interest in the therapeutic potential of cannabidiol (CBD) across a range of psychiatric disorders. CBD has been found to reduce anxiety during experimentally-induced stress in anxious individuals and healthy controls. However, the mechanisms underlying the putative anxiolytic effects of CBD are unknown. We therefore sought to investigate the behavioural and neural effects of a single dose of CBD vs. placebo on a range of emotion-related measures to test cognitive-mechanistic models of its effects on anxiety.MethodsWe conducted a randomised, double-blind, placebo-controlled, crossover, acute oral challenge of 600 mg of CBD in 24 healthy participants on emotional processing, with neuroimaging (viewing emotional faces during fMRI) and cognitive (emotional appraisal) measures as well as subjective response to experimentally-induced anxiety.ResultsCBD did not produce effects on BOLD responses to emotional faces, cognitive measures of emotional processing, or modulate experimentally-induced anxiety, relative to placebo.ConclusionsGiven the rising popularity of CBD for its putative medical benefits, further research is warranted to investigate the clinical potential of CBD for the treatment of anxiety disorders.

Individual and combined effects of cannabidiol and Δ9-tetrahydrocannabinol on striato-cortical connectivity in the human brain

“…Previous reported work on this cohort (Study 1) has also shown that both strains of cannabis increase the self-report of psychotic-like symptoms (including thought and perceptual distortion, and cognitive disorganisation; Mokrysz et al, 2020 ). Subjective effects of the CBD dose in Study 2 were minimal ( Bloomfield et al, 2020b ), and no measures of psychotic-like effects were acquired. Prominent theories of schizophrenia highlight the role of (striatal) dopamine in aberrant salience attribution ( Howes and Nour, 2016 ), and this has been supported by experimental evidence from patients ( Ceaser and Barch, 2016 ).…”