The acute effects of oral ethanol on the hypothalamic‐pituitary‐adrenal axis in normal human subjects

Wj, Inder; Joyce, P.R.; Je, Wells; Mj, Evans; Mj, Ellis; Mattioli, Leone; Donald, R. A.

doi:10.1111/j.1365-2265.1995.tb02600.x

Cited by 50 publications

(17 citation statements)

References 29 publications

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“…Specifically, several types of social behaviors including partner preference have been correlated with microsatellite length. In addition to vasopressin’s involvement in social behaviors, the neuropeptide levels are also affected by ethanol drinking and thought to play a role in the development of tolerance (Linkola et al, 1978; Hoffman et al, 1990; Inder et al, 1995; Harding et al, 1996; Rivier and Lee, 1996; Madeira and Paula-Barbosa, 1999; Silva et al, 2002). In addition, while one laboratory reported no effects of avpr1a deletion on ethanol intake (Caldwell et al, 2006), a more recent study found increased ethanol intake in avpr1a knockout mice (Sanbe et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Identification of subpopulations of prairie voles differentially susceptible to peer influence to decrease high alcohol intake

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Ryabinin

2013

Front. Pharmacol.

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Peer influences are critical in the decrease of alcohol (ethanol) abuse and maintenance of abstinence. We previously developed an animal model of inhibitory peer influences on ethanol drinking using prairie voles and here sought to understand whether this influential behavior was due to specific changes in drinking patterns and to variation in a microsatellite sequence in the regulatory region of the vasopressin receptor 1a gene (avpr1a). Adult prairie voles’ drinking patterns were monitored in a lickometer apparatus that recorded each lick a subject exhibited during continuous access to water and 10% ethanol during periods of isolation, pair housing of high and low drinkers, and subsequent isolation. Analysis of fluid consumption confirmed previous results that high drinkers typically decrease ethanol intake when paired with low drinkers, but that a subset of voles do not decrease. Analysis of bout structure revealed differences in the number of ethanol drinking bouts in the subpopulations of high drinkers when paired with low drinkers. Lickometer drinking patterns analyzed by visual and by cross-correlation analyses demonstrated that pair housing did not increase the rate of subjects drinking in bouts occurring at the same time. The length of the avpr1a microsatellite did not predict susceptibility to peer influence or any other drinking behaviors. In summary, subpopulations of high drinkers were identified, by fluid intake and number of drinking bouts, which did or did not lower their ethanol intake when paired with a low drinking peer, and these subpopulations should be explored for testing the efficacy of treatments to decrease ethanol use in groups that are likely to be responsive to different types of therapy.

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Section: Introductionmentioning

confidence: 99%

Identification of subpopulations of prairie voles differentially susceptible to peer influence to decrease high alcohol intake

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Ryabinin

2013

Front. Pharmacol.

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“…In particular, hypothalamicpituitary-adrenal (HPA) system alterations have been shown in healthy controls after acute alcohol intake (Inder et al, 1995;Waltman et al, 1993). However, acute ingestion of ethanol seems to stimulate the HPA system only when adverse effects occur, presumably due to vasopressin, which is increasingly released during nausea and emesis (Inder et al, 1995). Compared to acute intoxication, withdrawal seems to be an even stronger stimulus for the HPA system (Adinoff et al, 1991;Heuser et al, 1988;Von Bardeleben et al, 1989).…”

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confidence: 98%

“…Acute and also chronic alcohol consumption are known to affect virtually all endocrine functions. In particular, hypothalamicpituitary-adrenal (HPA) system alterations have been shown in healthy controls after acute alcohol intake (Inder et al, 1995;Waltman et al, 1993). However, acute ingestion of ethanol seems to stimulate the HPA system only when adverse effects occur, presumably due to vasopressin, which is increasingly released during nausea and emesis (Inder et al, 1995).…”

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confidence: 99%

The Combined Dexamethasone‐Suppression/CRH‐Stimulation Test in Alcoholics During and After Acute Withdrawal

Hundt

Zimmermann

Pöttig

et al. 2001

Alcoholism Clin & Exp Res

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“…Extensive literature implicates oxytocin and AVP in regulation of PP (28,39,40), and although we found some effects of alcohol or sex on these neuropeptide levels in a few brain regions (Table S1), there were no significant interactions to indicate a role for either of these neuropeptides in the sex-specific effects of alcohol on behavior. Because the roles of oxytocin and vasopressin are so essential to pair bonding, and because the effects of alcohol on these neuropeptide systems have been described previously (41)(42)(43)(44)(45)(46)(47)(48)(49)(50), it would be worth pursuing further experiments testing whether these systems do play a role in the effect of alcohol on PP that is simply not detected in changes in cellular or fiber peptide levels at 24 h of cohabitation.…”

Section: Discussionmentioning

confidence: 99%

Drinking alcohol has sex-dependent effects on pair bond formation in prairie voles

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Ahern

Hostetler³

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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Alcohol use and abuse profoundly influences a variety of behaviors, including social interactions. In some cases, it erodes social relationships; in others, it facilitates sociality. Here, we show that voluntary alcohol consumption can inhibit male partner preference (PP) formation (a laboratory proxy for pair bonding) in socially monogamous prairie voles (Microtus ochrogaster). Conversely, female PP is not inhibited, and may be facilitated by alcohol. Behavior and neurochemical analysis suggests that the effects of alcohol on social bonding are mediated by neural mechanisms regulating pair bond formation and not alcohol's effects on mating, locomotor, or aggressive behaviors. Several neuropeptide systems involved in the regulation of social behavior (especially neuropeptide Y and corticotropin-releasing factor) are modulated by alcohol drinking during cohabitation. These findings provide the first evidence to our knowledge that alcohol has a direct impact on the neural systems involved in social bonding in a sexspecific manner, providing an opportunity to explore the mechanisms by which alcohol affects social relationships.anxiety | ethanol | substance use | oxytocin | vasopressin P rairie voles are a valuable animal model of social monogamy. Males and female mates form durable bonds in the wild and in the laboratory (1, 2), and the neural mechanisms of social bonding delineated in this model species have translated with high predictive validity to humans (3, 4). In both species, social reward and drug reward show striking parallels at the behavioral and neurobiological levels (5-9). Prairie voles are now being used to explore the interactions between social relationships and drug abuse (10)(11)(12)(13)(14)(15)(16)(17)(18)(19).We previously demonstrated that prairie voles voluntarily selfadminister substantial amounts of alcohol (ethanol) and can influence the drinking patterns of a social partner (16)(17)(18)(19), similar to social drinking in humans (20). Because alcohol is known to influence social bonds in humans (21-24), we asked here whether alcohol consumption can affect the formation of adult social attachments in prairie voles. Adult male and female prairie voles were paired for 24 h and simultaneously given access to alcohol (10% ethanol by volume in water) and water or only water. They were then tested in the 3-h partner preference (PP) test (PPT), which has proved to be a remarkably sensitive assay for assessing the effects of genetics (25, 26), early social environment (27), and a range of pharmacological agents on social bond formation (28, 29).Results PP was first measured in female prairie voles that drank alcohol during cohabitation without mating. Animals consumed 12.48 ± 1.03 (mean ± SE) grams of alcohol per kilogram of body weight (g/kg) in the 24-h drinking period and showed a 58 ± 5.7% preference for alcohol. Analysis of behavior in the PPT revealed a significant effect of stimulus animal (partner or stranger) on huddling time [F(1,56) = 26.86, P < 0.0001]; no main effect of alcohol on tot...

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The acute effects of oral ethanol on the hypothalamic‐pituitary‐adrenal axis in normal human subjects

Cited by 50 publications

References 29 publications

Identification of subpopulations of prairie voles differentially susceptible to peer influence to decrease high alcohol intake

Identification of subpopulations of prairie voles differentially susceptible to peer influence to decrease high alcohol intake

The Combined Dexamethasone‐Suppression/CRH‐Stimulation Test in Alcoholics During and After Acute Withdrawal

Drinking alcohol has sex-dependent effects on pair bond formation in prairie voles

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