The acute impact of local cooling versus local heating on human skin microcirculation using laser Doppler flowmetry and tissue spectrophotometry

Bender, Dominik; Tweer, Stephanie; Werdin, Frank; Rothenberger, Jens; Daigeler, Adrien; Held, Manuel

doi:10.1016/j.burns.2019.03.009

Cited by 15 publications

(7 citation statements)

References 31 publications

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“…To the authors’ knowledge, this response has not been observed in other studies and may also indicate improved microcirculatory flow properties that increase blood flow velocity in the venous-capillary vasculature. This would explain that the O2C BF meter detects a faster clearance of erythrocytes, leading to a decrease in rHb [19]. However, it should be critically noted in these considerations that although statistically significant results are available here, the observed value changes are relatively small, and it seems questionable whether the minimum detectable changes were exceeded.…”

Section: Discussionmentioning

confidence: 81%

Influence of high-energy laser therapy to the patellar tendon on its ligamentous microcirculation: a quasi-experiment

Brandl

Egner

Reisser³

et al. 2022

Preprint

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Laser therapeutic applications, such as the use of high energy lasers (HILT), are widely used in physical therapy, but basic studies on the mechanisms of action of HILT on tendinous/ligamentous tissue are largely lacking. The aim of this study was to investigate microcirculatory changes of the patellar tendon by HILT. 21 healthy volunteers were treated with HILT. Before and after the intervention, as well as 10 minutes later, the microcirculation was measured by noninvasive laser spectroscopy (O2C device). Tissue temperature was recorded at the measurement time points using thermography. Blood flow increased significantly by 86.38 AU (p < 0.001) after the intervention and by 25.76 AU (p < 0.001) at follow-up. Oxygen saturation increased by 20.14% (p < 0.001) and 13.48%, respectively (p < 0.001), whereas relative hemoglobin decreased by 6.67 AU and 7.90 AU, respectively. Tendon temperature increased by 9.45° and 1.94° Celsius, respectively. Acceleration of blood flow by improving the flow properties of erythrocytes and platelets may have caused the results.

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Section: Discussionmentioning

confidence: 81%

Influence of high-energy laser therapy to the patellar tendon on its ligamentous microcirculation: a quasi-experiment

Brandl

Egner

Reisser³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…To the authors’ knowledge, this response has not been observed in other studies examining only heat-dependent effects and may indicate improved microcirculatory flow properties that increased blood flow velocity in the venous-capillary vasculature. This would explain that the O2C device detected a faster clearance of erythrocytes, leading to a decrease in rHb [ 26 ]. However, it should be critically noted in these considerations that although statistically significant results are available here, the observed value changes are relatively small, and it seems questionable whether the minimum detectable changes were exceeded.…”

Section: Discussionmentioning

confidence: 99%

Influence of high-energy laser therapy to the patellar tendon on its ligamentous microcirculation: An experimental intervention study

Brandl

Egner

Reisser³

et al. 2023

PLoS ONE

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Laser therapeutic applications, such as the use of high energy lasers (HILT), are widely used in physical therapy, but basic studies on the mechanisms of action of HILT on tendinous/ligamentous tissue are largely lacking. The aim of this study was to investigate microcirculatory changes of the patellar tendon by HILT. 21 healthy volunteers were included in the present investigation. Before and after HILT, as well as 10 minutes later, the microcirculation was measured by noninvasive laser Doppler and white light spectroscopy (O2C device). Tissue temperature was recorded at the measurement time points using thermography. Blood flow increased significantly by 86.38 arbitrary units (AU; p < 0.001) after the intervention and by 25.76 AU (p < 0.001) at follow-up. Oxygen saturation increased by 20.14% (p < 0.001) and 13.48%, respectively (p < 0.001), whereas relative hemoglobin decreased by 6.67 AU and 7.90 AU, respectively. Tendon temperature increased by 9.45° and 1.94° Celsius, respectively. Acceleration of blood flow by improving the flow properties of erythrocytes and platelets may have caused the results. HILT could be a therapeutic perspective for tendon pathologies with impaired microcirculation, although further studies are needed to validate the experimental results.

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“…Recent burn injury literature has found a strong association between cooling after thermal injury and a reduction in burn injury severity, with the mechanisms of this effect extending beyond dissipation of heat, to include the alteration of cellular behavior through (i) decreasing release of lactate and histamine, (ii) stabilizing thromboxane and prostaglandin levels, (iii) slowing local metabolism, (iv) altering membrane permeability, and (iv) inhibiting kallikrein activity 14 . The growing understanding of the local effects of hypothermia in burn injury provides a mechanistic underpinning for the significant safety benefit seen with the esophageal cooling device utilized in this study 15 . Proactive esophageal cooling allows for the contiguous placement of the sequential lesions without interruption and without the need to pause for local overheating conditions or temperature alarms, likely due to the mechanisms described above.…”

Section: Kautzner Et Al In the Efficas II Study Developedmentioning

confidence: 99%

Determination of Continuity Index Values in Atrial Fibrillation Ablation with Proactive Esophageal Cooling

Lazarus,

Sherman,

Putzel

et al. 2024

JoVE

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Radiofrequency (RF) ablation to perform pulmonary vein isolation (PVI) for the treatment of atrial fibrillation involves some risk to collateral structures, including the esophagus. Proactive esophageal cooling using a dedicated device has been granted marketing authorization by the Food and Drug Administration (FDA) to reduce the risk of ablation-related esophageal injury due to RF cardiac ablation procedures, and more recent data also suggest that esophageal cooling may contribute to improved longterm efficacy of treatment. A mechanistic underpinning explaining these findings exists through the quantification of lesion placement contiguity defined as the Continuity Index (CI). Kautzner et al. quantified the CI by the order of lesion placement, such that whenever a lesion is placed non-adjacent to the prior lesion, the CI is incremented by the number of segments the catheter tip has moved over.To facilitate real-time calculation of the CI and encourage further adoption of this instrument, we propose a modification in which the placement of non-adjacent lesions increments the CI by only one unit, avoiding the need to count potentially nebulous markers of atrial segmentation. The objective of this protocol is to describe the methods of calculating the CI both prospectively during real-time PVI cases and retrospectively using recorded case data. A comparison of the results obtained between cases that utilized proactive esophageal cooling and cases that used luminal esophageal temperature (LET) monitoring is then provided.

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The acute impact of local cooling versus local heating on human skin microcirculation using laser Doppler flowmetry and tissue spectrophotometry

Cited by 15 publications

References 31 publications

Influence of high-energy laser therapy to the patellar tendon on its ligamentous microcirculation: a quasi-experiment

Influence of high-energy laser therapy to the patellar tendon on its ligamentous microcirculation: a quasi-experiment

Influence of high-energy laser therapy to the patellar tendon on its ligamentous microcirculation: An experimental intervention study

Determination of Continuity Index Values in Atrial Fibrillation Ablation with Proactive Esophageal Cooling

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