The Acute Inhalation Toxicology of Chlorine Pentafluoride

Acute Toxicity of Thionyl Chloride Vapor for Rats

“…The acute effects of exposure to SOC12 were similar to those observed with exposure to other pulmonary irritants such as OF 2 (Davis, 1970), HF (DiPasquale and Davis, 1971), ClFs (Darmer, 1971), CF3 (Dost et al, 1967), and HCI (Darmer et al, 1972).…”

Environmental and health risks of chlorine trifluoride (ClF3), an alternative to potent greenhouse gases in the semiconductor industry

“…As demonstrated by Dost et al [11], the inhalation toxicity of ClF 3 on animals has been found that 800 ppm ClF 3 is lethal to rats in exposures of 15 min or more. In earlier similar experiments, Darmer et al [25] studied the acute toxicity of exposures of animals to the fluorinated oxidizers and HF, showing that ClF 3 was found to be far less toxic than oxygen difluoride (OF 2 ), only around half as toxic as chlorine pentafluoride (ClF 5 ), and about three to eight times as toxic as HF based on the LC 50 values (60-min exposure toxicity data). The LC 50 values for ClF 3 showed to be 299, 178 and 230 ppm for rats, mice and monkeys, respectively [25].…”

“…In earlier similar experiments, Darmer et al [25] studied the acute toxicity of exposures of animals to the fluorinated oxidizers and HF, showing that ClF 3 was found to be far less toxic than oxygen difluoride (OF 2 ), only around half as toxic as chlorine pentafluoride (ClF 5 ), and about three to eight times as toxic as HF based on the LC 50 values (60-min exposure toxicity data). The LC 50 values for ClF 3 showed to be 299, 178 and 230 ppm for rats, mice and monkeys, respectively [25]. Regarding its chronic toxicity, ClF 3 had no carcinogenic, reproductive, teratogenic, or mutagenic characteristics Due to its highly chemical reactivity, it is expected that ClF 3 should have significant health effects on human and has been recognized as physiologically toxic.…”

Immediately dangerous to life or health (IDLH) value profile: bromine pentafluoride [CAS no. 7789-30-2].

“…The mechanism of toxicity is the same as that of the other halogen causing localized irritation and tissue damage at the site of contact [NAS 2014]. In studies with rats, one found no lethality after exposure to 500 ppm bromine pentafluoride for 30 minutes [Dost et al 1970], while Darmer et al [1972] reported a 30-minute LC 50 value of 194 ppm for chlorine pentafluoride. This suggests that bromine pentafluoride is less toxic than chlorine pentafluoride.…”