2008
DOI: 10.1038/nn.2179
|View full text |Cite
|
Sign up to set email alerts
|

The acute light-induction of sleep is mediated by OPN4-based photoreception

Abstract: Sleep is regulated by both homeostatic and circadian mechanisms. The latter, termed 'process c', helps synchronize sleep-wake patterns to the appropriate time of the day. However, in the absence of a circadian clock, overall sleep-wake rhythmicity is preserved and remains synchronized to the external light-dark cycle, indicating that there is an additional, clock-independent photic input to sleep. We found that the direct photic regulation of sleep in mice is predominantly mediated by melanopsin (OPN4)-based p… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

15
223
2
4

Year Published

2008
2008
2022
2022

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 217 publications
(244 citation statements)
references
References 46 publications
15
223
2
4
Order By: Relevance
“…For wheel running activity, MO animals sustain the inhibitory responses to light similar to WT animals (26). However, in agreement with our threshold model, light induces sleep initially in MO animals but fails to sustain the response (Fig.…”
Section: Discussionsupporting
confidence: 86%
See 2 more Smart Citations
“…For wheel running activity, MO animals sustain the inhibitory responses to light similar to WT animals (26). However, in agreement with our threshold model, light induces sleep initially in MO animals but fails to sustain the response (Fig.…”
Section: Discussionsupporting
confidence: 86%
“…During the submission of this work, a study investigating the effects of light on WT animals, melanopsin-KO animals, and animals that lack rods and cones as a result of degeneration of the outer retina was published (26). There are similar findings between the two studies but also some fundamental differences; especially those concerning the role of rods-cones in sleep induction.…”
Section: Discussionmentioning
confidence: 92%
See 1 more Smart Citation
“…However, to date, lighting has not been optimised for the non-visual system and this will likely be a highly complex procedure. Firstly, it has been demonstrated, via physiological and behavioural studies in transgenic mice lacking specific photopigments, that the three photopigment classes contribute differentially to different non-visual responses Altimus et al, 2008;Lupi et al, 2008;Thompson et al, 2008;Tsai et al, 2009;Lall et al, 2010). Thus, optimal light for one situation/environment/population may not be effective or appropriate for another.…”
Section: Introductionmentioning
confidence: 99%
“…The role of melanopsin in multiple non-image forming (NIF) and image forming pathways Over the last 10-15 years, it has become clear that in addition to rods and cones, the mammalian retina contains a third class of ocular photoreceptor based upon a small number of photosensitive retinal ganglion cells (pRGCs) that express the blue-light sensitive vitamin A-based photopigment melanopsin (OPN4) [1][2][3] (for reviews see Hankins et al, 4 Hughes et al, 5 and Do and Yau 6 ). In the years following their identification, it has become clear that melanopsin expressing pRGCs contribute to a wide and diverse range of non-image forming (NIF) responses to light including circadian entrainment, 7,8 the pupillary light response (PLR), 9 negative masking of locomotor activity, 10 the regulation of sleep-wake states, [11][12][13][14] photophobia, and light aversion, 15,16 while also influencing mood-related behaviours and cognitive functions. 17 More recently it has become clear that melanopsin contributes not only to a range of NIF pathways but also performs multiple roles in image forming visual pathways.…”
mentioning
confidence: 99%