The Acute Perioperative Pain Service: Impact, Organization, and Future Directions

Al-Saidi, Ibrahim; Russell, Alex; Dizdarevic, Anis

doi:10.1007/s11916-023-01133-2

Cited by 4 publications

(1 citation statement)

References 36 publications

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“…Acute postoperative pain is described as acute pain in surgical patients stemming from multitude factors involving the activation of nociceptors, the inflammatory response, the activation of the sympathetic nervous system, and processes related to tissue repair and regeneration [ 1 , 2 ]. The World Health Organization and the International Association for the Study of Pain have acknowledged the treatment of postoperative pain as a fundamental human right that will not only enhance patient recovery and well-being but also lessen the economic burden on already constrained healthcare systems in developing countries [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Unraveling Catechol-O-Methyltransferase rs4680 SNP’s Role in Patients’ Response to Tramadol and Its Adverse Effects: A Pharmacogenetics Insight into Postoperative Pain Management

Khan,

Waheed,

Afsar

et al. 2023

JCM

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Effective postoperative pain management is essential for patient well-being and an efficient healthcare system. Variations in the Catechol O-Methyltransferase (COMT) gene, specifically rs4680, play a crucial role in pain perception and opioid response. This study seeks to elucidate the impact of rs4680 polymorphism on tramadol efficacy and adverse reactions in post-surgical patients. We performed an uncontrolled cohort pharmacogenetics study in which participants underwent postoperative tramadol administration. The frequencies of rs4680 alleles were determined and the association between rs4680 genotypes and the efficacy of tramadol analgesic as pain relief, measured by the Numeric Rating Scale (NRS), was analyzed. Secondary outcomes included tramadol-induced sedation levels, opioid-induced nausea and vomiting, and other adverse effects of tramadol. Data analysis, using IBM SPSS Statistics 23, focused on pain and side effect differences across genotypes, with statistical significance set to p ≤ 0.05. The COMT (rs4680) genotype distribution exhibited a ‘G’ allele frequency of 41.5% and an ‘A’ allele frequency of 58.5%, with the AA genotype present in 44% of individuals, adhering to the Hardy–Weinberg equilibrium (p = 0.788). Patients with the AA genotype reported lower pain scores post-tramadol administration across all times examined (p < 0.001), but also experienced statistically significant (p < 0.001) higher incidences of tramadol-induced nausea, vomiting, and sedation. However, GG genotype individuals experienced poor pain relief from tramadol, requiring more supplemental analgesia. These significant findings underscore the critical role of COMT rs4680 polymorphism in response to tramadol and the necessity of a personalized approach to postoperative pain management.

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Section: Introductionmentioning

confidence: 99%

Unraveling Catechol-O-Methyltransferase rs4680 SNP’s Role in Patients’ Response to Tramadol and Its Adverse Effects: A Pharmacogenetics Insight into Postoperative Pain Management

Khan,

Waheed,

Afsar

et al. 2023

JCM

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Transitional Pain Service: An Update

Klimke,

Ott,

Romero

et al. 2024

Curr Pain Headache Rep

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Purpose of Review Chronic Postsurgical Pain (CPSP) and the risk for long-term opioid dependency are known complications following major surgery. The idea of Transitional Pain Service (TPS) has been introduced as an interdisciplinary setting to manage pain in the perioperative continuum. We expand on the basic framework and principles of TPS and summarize the current evidence of the TPS and possible interventions to adress postoperative pain. Areas of future work in TPS-related research are discussed. Recent Findings Several studies support the effectiveness of TPS in reducing opioid consumption in the perioperative period and following discharge. Some studies also show an improvement in functional outcome with TPS with patients reporting lower pain severity and pain interference. Summary The TPS aims to halt the progress of acute postoperative pain to CPSP by providing longitudinal support with patient-centered care. While some studies suggest a positive impact of TPS implementation in terms of reduction in postoperative opioid consumption and improvement of some functional outcomes, direct evidence in terms of reduction in the incidence of CPSP is still missing. The cost-effectiveness of TPS and the expansion of TPS through e-health services and digital applications also need to be evaluated.

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The analgesic effectiveness of auriculotherapy for acute postoperative pain: A systematic review and meta-analysis

Zhang,

Xu,

Tang

et al. 2025

Complementary Therapies in Medicine

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The Acute Perioperative Pain Service: Impact, Organization, and Future Directions

Cited by 4 publications

References 36 publications

Unraveling Catechol-O-Methyltransferase rs4680 SNP’s Role in Patients’ Response to Tramadol and Its Adverse Effects: A Pharmacogenetics Insight into Postoperative Pain Management

Unraveling Catechol-O-Methyltransferase rs4680 SNP’s Role in Patients’ Response to Tramadol and Its Adverse Effects: A Pharmacogenetics Insight into Postoperative Pain Management

Transitional Pain Service: An Update

The analgesic effectiveness of auriculotherapy for acute postoperative pain: A systematic review and meta-analysis

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