The acute-phase response in endometriosis of women

Dunselman, G.A.J.; Bouckaert, P. X. J. M.; Evers, Johannes L.H.

doi:10.1530/jrf.0.0830803

Cited by 20 publications

(14 citation statements)

References 17 publications

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“…However, Dunselman and coworkers demonstrated that small proteins with a molecular weight <40 kDa could readily move between the vasculature and the peritoneal fluid [31]. Intraperitoneal injection with interleukin (IL)-4 was able to inhibit basic fibroblast growth factor (bFGF)-induced corneal neovascularization [32].…”

Section: Induction Of Angiogenesis In the Peritoneummentioning

confidence: 99%

Vascular development in endometriosis

et al. 2005

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Endometriosis, defined as the presence of endometrial tissue outside the uterus, is an estrogen-dependent disease which causes pelvic pain and subfertility in women of reproductive age. The condition has a dramatic impact on the professional, social and marital life of sufferers. Direct and indirect evidence suggests that angiogenesis is required for the development and persistence of endometriosis. In this review the state-of-the-art with regard to our understanding of the role of angiogenesis in the ectopic implantation and survival of menstrual endometrial tissue will be discussed.

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Section: Induction Of Angiogenesis In the Peritoneummentioning

confidence: 99%

Vascular development in endometriosis

et al. 2005

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“…Small molecules, such as urea and electrolytes, diffuse rapidly. Diffusion rates decrease with the molecular weight and become slow for molecules larger than 100,000 as molecular weight [30]. From this it can be anticipated that the concentrations of small molecules in peritoneal fluid and plasma are similar, whereas the concentrations of larger molecules from the blood stream are lower in peritoneal fluid.…”

Section: Introductionmentioning

confidence: 95%

Pathogenesis of Endometriosis: The Role of Peritoneal Fluid

Koninckx

Kennedy

1999

Gynecol Obstet Invest

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Peritoneal fluid is a specific microenvironment. It originates mainly as an ovarian exudation product due to increased vascular permeability, and contains large amounts of macrophages and their secretion products, which include growth factors, cytokines and angiogenic factors. Similarly, within the ovary, there is also a specific microenvironment, best characterised by the follicular milieu with steroid hormone concentrations that are 1,000 times higher than in plasma. Since endometrial cells in peritoneal fluid and superficially implanted cells will be influenced by peritoneal fluid concentrations, any differences found between minimal endometriosis and eutopic endometrium could be the consequence of their different local environments, rather than inherent cellular differences. Superficial endometrial implants may be regulated by factors in peritoneal fluid, while deep endometriosis and cystic ovarian endometriosis may be under the influence of factors in blood and within the ovary, in which case minimal endometriosis may be physiologic only, while deep endometriosis and cystic ovarian endometriosis, both associated with pelvic pain and infertility, may be a pathological state. In conclusion, the local endocrine environment, that is, in blood, peritoneal fluid, and within the ovary, should be taken into account to explain the differences between superficial, deep and cystic ovarian endometriosis, together with inherent differences in the endometrial cells of women with and without endometriosis.

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“…The increasing level of CRP and ESR in pelvic peritoneum due to inflammation process can also be detected in blood serum. 12 However, measurement of CRP and ESR from our research did not appear to be advantageous for determining the severity of endometriosis. There was no association between CRP level and stage of the disease.…”

Section: Discussionmentioning

confidence: 60%

“…11 Although the pathogenesis of endometriosis is still controversial, growing evidence indicate a significant role of inflammatory factors involved in the development of endometriosis. 12,13 Biomarker such as CRP and ESR are acute phase proteins that increased when inflammation occurs. It has been suggested that in women with endometriosis there is an inflammatory reaction of the pelvic peritoneum.…”

Section: Discussionmentioning

confidence: 99%

Moderate-Severe Endometriosis Shows Higher CA-125 Serum Level Compared to Minimal-Mild Endometriosis

Yudho

2016

Indones J Obstet Gynecol

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Objective: To investigate and compare serum profile of CA-125, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) in various stages of endometriosis. Methods: Forty endometriosis patients’ blood samples were taken prior to laparoscopic surgery for various indications. Diagnosis of endometriosis was confirmed by laparoscopy. Independent T test methods were used for statistical analysis. ROC analysis was examined for each variable. Results: The mean level of CA-125 serum was 12.0 vs. 36.3 U/ml (p < 0.05); ESR serum was 11 vs. 12.8 mm/hour (p > 0.05); CRP serum was 0.7 vs. 0.3 (p > 0.05) for endometriosis stage I-II and stage III-IV, respectively. The optimal cut off point to discriminate endometriosis stage I-II and III-IV was 16.9 U/ml with sensitivity 83% and specificity 81%. Conclusion: The CA-125 serum level was increased for moderatesevere compare to minimal mild endometriosis patient. [Indones J Obstet Gynecol 2012; 36-3: 121-4] Keyword: CA-125, CRP, endometriosis, ESR, serum

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The acute-phase response in endometriosis of women

Abstract: Summary. Peritoneal

Cited by 20 publications

References 17 publications

Vascular development in endometriosis

Vascular development in endometriosis

Pathogenesis of Endometriosis: The Role of Peritoneal Fluid

Moderate-Severe Endometriosis Shows Higher CA-125 Serum Level Compared to Minimal-Mild Endometriosis

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