The acute postprandial response of homocysteine to multivitamin and mineral supplementation with a standard meal is not impaired in older compared to younger adults

Gillies, Nicola; Sharma, Pankaja; Han, Seung Baik; Teh, Ruth; Fraser, Karl; Roy, Nicole C.; Cameron‐Smith, David; Milan, Amber M.

doi:10.1007/s00394-022-03068-7

Cited by 2 publications

(1 citation statement)

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“…A trend for a decline of homocysteine levels is observed after the consumption of all meals (7-11%) which reached significant levels at 90 min for BU, BU-IBU and OO and at 240 min for BU, OO and OO500. A similar acute decline of homocysteine was observed after the consumption of a mixed meal in both younger and older adults [47]. The micronutrient and amino acid profile of a mixed meal provide metabolites and amino acids such as choline, betaine and folic acid that may acutely affect postprandial homocysteine degradation.…”

Section: Discussionmentioning

confidence: 57%

Acute Antiplatelet Effects of an Oleocanthal-Rich Olive Oil in Type II Diabetic Patients: A Postprandial Study

Katsa,

Ketselidi,

Kalliostra

et al. 2024

IJMS

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Postprandial dysmetabolism is a common entity of type 2 diabetes mellitus (T2DM) and may act as a daily stressor of the already dysfunctional diabetic platelets. This study aims to investigate whether oleocanthal-rich olive oils (OO), incorporated into a carbohydrate-rich meal, can affect postprandial dysmetabolism and platelet aggregation. Oleocanthal is a cyclooxygenase inhibitor with putative antiplatelet properties. In this randomized, single-blinded, crossover study, ten T2DM patients consumed five isocaloric meals containing 120 g white bread combined with: (i) 39 g butter, (ii) 39 g butter and 400 mg ibuprofen, (iii) 40 mL OO (phenolic content < 10 mg/Kg), (iv) 40 mL OO with 250 mg/Kg oleocanthal and (v) 40 mL OO with 500 mg/Kg oleocanthal. Metabolic markers along with ex vivo ADP- and thrombin receptor-activating peptide (TRAP)-induced platelet aggregation were measured before and for 4 h after the meals. The glycemic and lipidemic response was similar between meals. However, a sustained (90–240 min) dose-dependent reduction in platelets’ sensitivity to both ADP (50–100%) and TRAP (20–50%) was observed after the oleocanthal meals in comparison to OO or butter meals. The antiplatelet effect of the OO containing 500 mg/Kg oleocanthal was comparable to that of the ibuprofen meal. In conclusion, the consumption of meals containing oleocanthal-rich OO can reduce platelet activity during the postprandial period, irrespective of postprandial hyperglycemia and lipidemia.

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Section: Discussionmentioning

confidence: 57%