The acute response of plasma brain-derived neurotrophic factor as a result of exercise in major depressive disorder

Gustafsson, G; Lira, Claudia Mallea; Johansson, Jon; Wisén, Anita; Wohlfart, Björn; Ekman, Rolf; Westrin, Åsa

doi:10.1016/j.psychres.2008.06.030

Cited by 99 publications

(67 citation statements)

References 25 publications

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“…Human studies on the effects of exercise-induced BDNF changes in depressed populations are still preliminary, although BDNF levels were transiently increased in elderly women with remitted major depression (Laske et al, 2010) and in unmedicated patients suffering from major depressive disorder (Gustafsson et al, 2009). …”

Section: Exercise and Its Effect On Neuroprogressionmentioning

confidence: 99%

A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise

Lopresti

Hood

Drummond

2013

Journal of Affective Disorders

529

412

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Research on major depression has confirmed that it is caused by an array of biopsychosocial and lifestyle factors. Diet, exercise and sleep are three such influences that play a significant mediating role in the development, progression and treatment of this condition. This review summarises animal and human-based studies on the relationship between these three lifestyle factors and major depressive disorder, and their influence on dysregulated pathways associated with depression, namely neurotransmitter processes, immuno-inflammatory pathways, hypothalamic-pituitary-adrenal (HPA) axis disturbances, oxidative stress and antioxidant defence systems, neuroprogression, and mitochondrial disturbances. Increased attention in future clinical studies on the influence of diet, sleep and exercise on major depressive disorder and investigations of their effect on physiological processes will help to expand our understanding and treatment of major depressive disorder. Mental health interventions, taking into account the bidirectional relationship between these lifestyle factors and major depression are also likely to enhance the efficacy of interventions associated with this disorder.

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Section: Exercise and Its Effect On Neuroprogressionmentioning

confidence: 99%

A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise

Lopresti

Hood

Drummond

2013

Journal of Affective Disorders

529

412

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“…This was different from our study since our subjects remained on self-selected-intensity-tolow-intensity exercises being a conventional gait training method, and did not increase intensity over the forty-minute walk. These data show that elevated serum levels of BDNF are dependent on exercise type and intensity [37,38].…”

Section: Discussionmentioning

confidence: 60%

No Change in Brain-Derived Neurotrophic Factor Levels Following a Single Session of Light to-Moderate Intensity Walk in Chronic Stroke Patients

Silva¹,

Morais²,

Santos³

et al. 2017

J Neurol Disord

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“…There are few studies that analyzed the relationship between serum BDNF levels and aerobic exercise in patients with depression [113][114][115][116][117] (for review, see Tables 1 and 2). Gustafsson et al [113] evaluated the response of plasma BDNF during incremental cycloergometer test.…”

Section: The Effect Of Aerobic Exercise On the Plasma Or Serum Bdnf Cmentioning

confidence: 99%

“…Gustafsson et al [113] evaluated the response of plasma BDNF during incremental cycloergometer test. The study included 36 adult individuals of both genders, with 18 in the control group (34.5 years) and 18 belonging to the group with moderate depression (33.5 years).…”

Section: The Effect Of Aerobic Exercise On the Plasma Or Serum Bdnf Cmentioning

confidence: 99%

Aerobic Exercise Does Not Predict Brain Derived Neurotrophic Factor And Cortisol Alterations in Depressed Patients

Lamego¹,

Moura²,

Paes³

et al. 2015

CNSNDDT

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The pathophysiology of depression is related to neurobiological changes that occur in the monoamine system, hypothalamic-pituitary-adrenal axis, neurogenesis system and the neuroimmune system. In recent years, there has been a growing interest in the research of the effects of exercise on brain function, with a special focus on its effects on brainderived neurotrophic factor (BDNF), cortisol and other biomarkers. Thus, the aim of this study is to present a review investigating the acute and chronic effects of aerobic exercise on BDNF and cortisol levels in individuals with depression. It was not possible to establish an interaction between aerobic exercise and concentration of BDNF and cortisol, which may actually be the result of the divergence of methods, such as type of exercises, duration of the sessions, and prescribed intensity and frequency of sessions.

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The acute response of plasma brain-derived neurotrophic factor as a result of exercise in major depressive disorder

Cited by 99 publications

References 25 publications

A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise

A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise

No Change in Brain-Derived Neurotrophic Factor Levels Following a Single Session of Light to-Moderate Intensity Walk in Chronic Stroke Patients

Aerobic Exercise Does Not Predict Brain Derived Neurotrophic Factor And Cortisol Alterations in Depressed Patients

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