The Acute Retinal Necrosis Syndrome

Culbertson, William W.; Blumenkranz, Mark S.; Haines, Harold G.; Gass, J. Donald M.; Mitchell, Kenneth B.; Norton, Edward W.D.

doi:10.1016/s0161-6420(82)34638-2

Cited by 233 publications

(28 citation statements)

References 29 publications

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“…Monoacterized by an acute peripheral necrotizing retinitis, retinal nuclear cell infiltrates, primarily plasma cells and lymphocytes, arteritis, vitreitis, and panuveitis [1 -4]. As the disease prohave been demonstrated in the choroid beneath the necrotic gresses, necrosis of the entire retina and complications such as retina, in the vitreous cavity, and in the anterior segment of retinal detachment can lead to additional visual deterioration inflamed eyes [6,7,12]. T cells predominate among the in- [5].…”

Section: Acute Retinal Necrosis (Arn) In Humans Is a Retinal Diseasementioning

confidence: 99%

“…In an experimental mouse model of ARN, uniocular inoculaintraocular fluid (IOF) from ARN patients, isolation attempts of tion of HSV-1 into the anterior chamber of euthymic mice the virus from ocular fluid samples are usually unsuccessful induces an iridocyclitis with sparing of the retina of the injected [6,9,12]. In most cases, however, the causative agent can be eye [14 -17, 21 -25].…”

Section: Acute Retinal Necrosis (Arn) In Humans Is a Retinal Diseasementioning

confidence: 99%

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T Cells Specific for the Triggering Virus Infiltrate the Eye in Patients with Herpes Simplex Virus-Mediated Acute Retinal Necrosis

Verjans¹,

Feron²,

Dings³

et al. 1998

Journal of Infectious Diseases

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Acute retinal necrosis (ARN) is a rare, potentially blinding retinal disease resulting from ocular infections with herpes simplex virus (HSV) or varicella-zoster virus (VZV). To determine the antigen specificity and functional characteristics of ocular infiltrating T cells in ARN, T cells were isolated and expanded nonspecifically from intraocular fluid (IOF) samples from 2 patients with HSV-1- and 3 with VZV-mediated ARN. HSV-specific T cell reactivity could be detected only in the IOF-derived T cell lines (TCLs) of the 2 patients with HSV-mediated ARN. These TCLs consisted of both HSV type-common and type-specific CD4+ and CD8+ T cell clones (TCCs) with differential T cell receptor usage. Irrespective of their phenotype, the TCCs were cytolytic and secreted interferon-gamma, tumor necrosis factor-alpha, interleukin-4, and interleukin-5. In both patients, the antigen specificity of a substantial number of HSV-1-specific TCCs could be mapped to approximately 0.67-0.73 HSV-1 map units. The data presented suggest the contribution of T cells, specific for the triggering virus, to the pathogenesis of ARN.

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Section: Acute Retinal Necrosis (Arn) In Humans Is a Retinal Diseasementioning

confidence: 99%

Section: Acute Retinal Necrosis (Arn) In Humans Is a Retinal Diseasementioning

confidence: 99%

T Cells Specific for the Triggering Virus Infiltrate the Eye in Patients with Herpes Simplex Virus-Mediated Acute Retinal Necrosis

Verjans¹,

Feron²,

Dings³

et al. 1998

Journal of Infectious Diseases

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“…The causative agents are VZV, HSV-1, HSV-2, and rarely, CMV or Epstein–Barr virus 46,47. Data from a British registry reported an incidence of 0.5–0.63 patients/year of ARN, a number that remained fairly stable over the last decade and has been recently confirmed in a German survey 48,49.…”

Section: Herpes Virus-associated Posterior Uveitismentioning

confidence: 94%

Current aspects on the management of viral uveitis in immunocompetent individuals

Pleyer

Chee

2015

OPTH

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Viruses are a fundamental etiology of ocular inflammation, which may affect all structures of the organ. Advances in molecular diagnostics reveal an increasingly broader spectrum of virus-associated intraocular inflammation, including all members of the herpes family, rubella virus, and other more rare causes such as Epstein–Barr and chikungunya virus. In particular, viruses of the herpes family are important causes of anterior and posterior uveitis. Owing to their often fulminant clinical course and persistence in ocular tissues, a clear differential diagnosis between alpha- and beta-type herpes viruses is essential to guide acute and long-term treatment. Here, we review the epidemiology, clinical, and laboratory findings of virus-associated uveitis with emphasis on their therapy and management and include our own experience.

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“…Cytocen¬ trifuge preparations were fixed for ten minutes in a combination of cold acetic acid and acetone and blocked for 30 minutes with PBS containing 10% normal goat serum. After washing with PBS/ FACS, 100 ph of diluted FITC goat antihuman Ig (Fab 2 fragment) was added for 6. Although the clinical disease has a distinctive course and manifestation, it was included in idiopathic uveitis since its cause is not known.…”

Section: Methodsmentioning

confidence: 99%