The Acylation of Aldoximes. V.<sup>1</sup> Isomerizations in the Benzoylation of syn- and anti-Aldoximes in Pyridine

Vermillion, Gertrude; Hauser, Charles R.

doi:10.1021/ja01868a015

Cited by 7 publications

(1 citation statement)

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“…Paraoxou were administered subcutaneously in aq solution (mice. 10 ml/kg of body weight; rat s,2.5 ml/kg of bodv weight). Atropine sulfate Wits administered ip, 1.5 min after intoxication, in aq solution (mice.…”

Section: Hakdixu Wdkzixaimentioning

confidence: 99%

Isothiazolecarboxaldoximes and methylated derivatives as therapeutic agents in poisoning by organophosphorus compounds

Benschop¹,

Oosten²,

Platenburg³

et al. 1970

J. Med. Chem.

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As part of a search for biological activity in compounds containing strong electron-withdrawing groups directly attached to C=(), a series of derivatives of perfluoroalkyl aldehydes and perfluoroalkyl acids were subjected to biological evaluation. Interesting and diverse activities were found in derivatives of trifluoroacetaldehyde: in contrast, derivatives of longer chain fluorinated aldehydes and acids showed little activity. The active compounds which, it is suggested, may act by releasing CFjCHO in the body of the test animal have effects on the endocrine glands and the CNS and reduce inflammation induced by carrageenin. Koine of these show potent, but temporary, antifertility activity in male rats.Carbonyl derivative* of o-membered heterocyclic rings, substituted with strong electron-withdrawing groups, have been the subject of numerous publicat ions.1

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Section: Hakdixu Wdkzixaimentioning

confidence: 99%