Information mutations are unintended changes in information that can lead to the establishment of poorly adapted cultural traits in local medical systems. The use of plant mixtures in local medical systems, such as "bottles and lickers" could it be an important model to understand this phenomenon, since the variability of information associated with one plant mixture is high and may lead to increased errors during social transmition. In this study, we sought to investigate whether the socioeconomic variables: gender, age, and education influence the amount of information mutations on the knowledge of plant mixtures. Data collection followed the ethical parameters for research with human beings and consisted of two different applications of semi-structured interviews to access and analyze the Information Unit (IU) in regard to the transfer of information mutations between the individual learner and the individual giving information. We obtained 141 types of plant mixtures mentioned in the study. When analyzing our variables, age and education influenced the number of mutations (p < 0.0008). Younger individuals had more information mutations about plant mixtures, and less educated individuals had less information mutations than those with more education (p < 0.006). Thus, we encourage ethnobotanical research in other regions of the country to contribute to the effectiveness of information transmitted about medicinal plants in local medical systems.