This paper addresses the control of a hexapod robot’s foot trajectory tracking using an adaptive sliding mode control (SMC) approach based on Udwadia–Kalaba theory. Unlike the traditional control approach, the Udwadia–Kalaba theory allows for the transformation of the hexapod robot foot trajectory tracking control problem into a system servo binding solution problem. This method eliminates the requirement to linearize the nonlinear system. The system may contain uncertainties, such as less-than-ideal initial circumstances and vibration disturbances during operation, which have an impact on the control precision due to mistakes in modeling, measurements, and changes in operational states. To deal with the uncertainty, the adaptive SMC controller was developed. The stability analysis is carried out using the second Lyapunov function method. By modeling the hexapod robot’s legs and running simulations to compare the simulated tracking route to the planned trajectory, the precision and stability of the control approach suggested in this study are finally demonstrated, and by comparing with the simulation results of adaptive robust control strategy, the advantages of RBF neural network adaptive SMC strategy are obtained.