The adaptive transport of folic acid in the intestine of laying hens with increased supplementation of dietary folic acid

Tactacan, G. B.; Rodríguez-Lecompte, J. C.; House, James D.

doi:10.3382/ps.2011-01711

Cited by 13 publications

(5 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results are in agreement with the findings of Tactacan et al (2012), who found that the egg and plasma folate concentrations of birds fed 10 or 100 mg of FAsupplemented diets significantly increased compared with those of birds fed the control diet. A proportionate increase in both plasma folate and egg folate concentrations is an indication that circulating blood folate are transferred efficiently into the egg (Sherwood et al, 1993;House et al, 2002;Hebert et al, 2005).…”

Section: Plasma Folic Acid and Egg Folate Contentsupporting

confidence: 93%

Effect of Dietary Folic Acid Supplementation to Diets of Low Levels of Energy and Methionine of Developed Laying Hens in Summer Season on Performance, Physiological Status and Immune Response

Nofal¹,

Samak²,

Alderey³

et al. 2018

Journal of Animal and Poultry Production

View full text Add to dashboard Cite

The objective of this study was to evaluate the effect of different levels of folic acid (FA) supplementation on productive and physiological performance and immune response of laying hens fed diets varying in methionine (M) and metabolizable energy (ME) levels. A total number of two hundred and sixteen of Silver Montazah laying hens (28 weeks old), were randomly divided into 12 treatment groups (18 hens / each). All birds were housed in individual cages. The experimental design was conducted in 2 x 2 x 3 factorial arrangement of treatments, 2 levels of ME (2800 and 2600 Kcal/Kg diet), two levels of DL-methionine (0.40% and 0.30%) and three levels of folic acid (0.0, 10, and 20 mg /kg feed). The results can be summarized as follows:-Increasing ME significantly increased final body weight (P≤0.01), shell thickness (P≤0.01), plasma total protein, globulin, glucose, cholesterol, triglycerides, egg folate content and hatchability of total fertile eggs while, daily feed intake and feed conversion ratio (FCR) were decreased. -Methionine at a level of 0.40% in the diet increased significantly egg number, albumin%, plasma total protein, globulin and HDL. On the other hand daily feed intake, FCR, shell%, egg shape index% and egg specific gravity were significantly decreased.-Significant increases were observed in egg number, shell thickness, plasma total protein, globulin and egg folate content due to increasing FA supplementation in the diet while, Haugh units, plasma albumin and plasma folate recorded significantly their lowest values.-Feeding hens diet with ME of 2800 kcal/kg and a level of 0.40% M without FA supplementation significantly increased albumen % and plasma triglycerides. In this respect, FA supplementation at a level of 10 mg/kg diet significantly increased plasma HDL. On the other side, FA supplementation at a level of 20 mg/kg diet significantly increased body weight change, daily egg mass, shell thickness, plasma total protein, albumin, globulin and significantly improved hatchability of fertile eggs. In addition, antibody titre against NDV recorded the highest value with insignificant difference as compared to other treatments.-Hens fed diet with 2600 kcal/kg ME and a level of 0.30% M without FA supplementation laid eggs with the highest mean of specific gravity while increasing FA to 10 mg/kg decreased plasma HDL. Increasing the supplementation level of FA in the diet significantly increased daily feed intake while, plasma triglycerides was significantly decreased.-A significant increase was observed in Haugh units attributed to feeding hens diet of ME at level of 2600 kcal/kg and 0.40% M without FA supplementation.

show abstract

Section: Plasma Folic Acid and Egg Folate Contentsupporting

confidence: 93%

Effect of Dietary Folic Acid Supplementation to Diets of Low Levels of Energy and Methionine of Developed Laying Hens in Summer Season on Performance, Physiological Status and Immune Response

Nofal¹,

Samak²,

Alderey³

et al. 2018

Journal of Animal and Poultry Production

View full text Add to dashboard Cite

show abstract

“…intake would be needed to induce toxicity. Though there are limited studies on feeding high doses of FA to broiler chickens, recent studies with laying hens have demonstrated non-toxicity of high doses of FA (Tactacan et al 2012). A possible explanation for the reduced growth performance in chickens fed 10 ppm FA in the current study is the metabolic relationship between FA and methionine.…”

Section: Resultsmentioning

confidence: 63%

Effect of dietary energy density and folic acid supplementation on white striping occurrence and growth performance of broiler chickens

2021

View full text Add to dashboard Cite

Broilers were allocated to eight treatments consisting of two energy levels: Normal (NE) and High (HE), and four folic acid (FA) levels (2.2, 5, 10 and 15 ppm). On d 42, two male and two female chickens were euthanized per pen and white striping (WS) evaluation was performed on the Pectoralis major. Birds fed HE diets had reduced (P<0.05) FI and FCR than those on NE diets. With increasing FA levels, there was reduced (P<0.05) WS score, increased (P<0.05) normal breast fillet percentage in female but not in the male chickens. WS scores were higher (P<0.01) in male chickens than in the females.

show abstract

“…Some studies were identified in the literature search reporting deposition of folates in food of animal origin. The FEEDAP Panel noted that new data derived from publications by Tactacan et al (2012), Altic et al (2016) and Bagheri et al (2019), all concerning deposition in the eggs, give very similar values to those retained in the former EFSA assessment (EFSA FEEDAP Panel, 2012). The study by Czarnowska-Kujawska et al (2020) concerning the deposition of folates in livers of chickens, turkeys, pigs and beef collected in retail/butchers, shows high deposition values however, no information was provided in the publication whether the samples were obtained from animals fed with folic acid-supplemented diets.…”

Section: Safety For the Consumersmentioning

confidence: 99%

“…The FEEDAP Panel noted that new data derived from publications by Tactacan et al. (2012), Altic et al. (2016) and Bagheri et al.…”

Section: Assessmentmentioning

confidence: 99%

Assessment of the feed additive consisting of folic acid for all animal species for the renewal of its authorisation (Chr. Olesen A/S and DSM Nutritional Products Ltd)

Bampidis,

Azimonti,

Bastos

et al. 2023

EFS2

View full text Add to dashboard Cite

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the assessment of the application for the renewal of the authorisation of folic acid as a nutritional feed additive. The additive is authorised for use in feed and water for drinking for all animal species. The applicant provided evidence that the additive currently in the market complies with the existing conditions of authorisation and the production process has not been modified. The FEEDAP Panel considers that there is no evidence to revise the conclusions reached in the previous assessment for the safety for the terrestrial species, consumers and for the environment. The use of folic acid in aquatic animal species to cover their nutritional needs is considered safe. However, the Panel is not in a position to set a maximum safe level for all fish and crustacean species. Considering the narrow margin between the requirement and the tolerated levels seen in some aquatic animal species, the FEEDAP Panel considers that supplementation should not exceed the requirements of the different aquatic animal species. The additive is neither a skin irritant nor a dermal sensitiser. The exposure through inhalation is likely. Due to the lack of data, the FEEDAP Panel is not in the position to conclude on the potential of folic acid to be harmful to the respiratory system and irritant to eyes. The Panel retains that the previously made conclusion on the efficacy remains valid.

show abstract

The adaptive transport of folic acid in the intestine of laying hens with increased supplementation of dietary folic acid

Cited by 13 publications

References 22 publications

Effect of Dietary Folic Acid Supplementation to Diets of Low Levels of Energy and Methionine of Developed Laying Hens in Summer Season on Performance, Physiological Status and Immune Response

Effect of Dietary Folic Acid Supplementation to Diets of Low Levels of Energy and Methionine of Developed Laying Hens in Summer Season on Performance, Physiological Status and Immune Response

Effect of dietary energy density and folic acid supplementation on white striping occurrence and growth performance of broiler chickens

Assessment of the feed additive consisting of folic acid for all animal species for the renewal of its authorisation (Chr. Olesen A/S and DSM Nutritional Products Ltd)

Contact Info

Product

Resources

About