The AdcR-regulated AdcA and AdcAII contribute additively to zinc acquisition and virulence in Streptococcus suis

Zheng, Chengkun; Qiu, Jun; Zhao, Xiaoxian; Yu, Sijia; Wang, Hong; Wan, Mengyan; Wei, Min; Jiao, Xinan

doi:10.1016/j.vetmic.2022.109418

Cited by 7 publications

(1 citation statement)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The role of Zn transport in virulence is clear as Adc mutants in a variety of Streptococcal species have attenuated disease severity and/or colonization in experimental animal models such as rat tooth colonization, nasopharynx infection, meningitis, and skin infection [ 2 , 28 , 40 , 59 , 100 , 101 ]. The regulator AdcR has also been shown to play a role in virulence as the negative regulator of the Zn import system, as well as regulating other factors such as capsule biosynthesis in S. pyogenes [ 57 , 78 , 88 , 90 , 102 ]. It was recently speculated that Zn sequestration by CP may also have a beneficial effect on pathogenic bacteria by preventing the irreversible binding of Zn 2+ to the SBP of the manganese transport system, which then inhibits manganese uptake in S. pneumoniae [ 103 ].…”

Section: Zincmentioning

confidence: 99%

Metal Homeostasis in Pathogenic Streptococci

2022

View full text Add to dashboard Cite

Streptococcus spp. are an important genus of Gram-positive bacteria, many of which are opportunistic pathogens that are capable of causing invasive disease in a wide range of populations. Metals, especially transition metal ions, are an essential nutrient for all organisms. Therefore, to survive across dynamic host environments, Streptococci have evolved complex systems to withstand metal stress and maintain metal homeostasis, especially during colonization and infection. There are many different types of transport systems that are used by bacteria to import or export metals that can be highly specific or promiscuous. Focusing on the most well studied transition metals of zinc, manganese, iron, nickel, and copper, this review aims to summarize the current knowledge of metal homeostasis in pathogenic Streptococci, and their role in virulence.

show abstract