The added value of a portable gamma camera for intraoperative detection of sentinel lymph node in squamous cell carcinoma of the oral cavity: A case report

Mayoral, María; Paredes, Pilar; Sieira, R.; Vidal-Sicart, Sergi; Marti, Carles Morte; Pons, Françesca

doi:10.1016/j.remn.2013.12.007

Cited by 5 publications

(3 citation statements)

References 10 publications

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“…Aside from fhSPECT navigation, there are other possibilities for intraoperative sentinel node imaging such as portable gamma cameras [21][22][23][24] and fusion ultrasound/…”

Section: Emerging Developments For Sln Biopsy In Hn Cancermentioning

confidence: 99%

Role of intraoperative sentinel node imaging in head and neck cancer

Schilling

Corrado

Gnanasegaran

et al. 2015

Clin Transl Imaging

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At the present time, there is a dilemma concerning the best management of the neck in patients presenting with early head and neck squamous cell carcinoma (HNSCC). Occult cervical metastasis is found in up to a quarter of HNSCC patients with radiologically N0 necks, and for this reason, conventional treatment includes elective neck dissection (END) alongside tumour excision. Sentinel node biopsy (SNB) offers an alternative accurate and minimally invasive method of staging the neck, which has been safely applied to oral cancer. SNB is a patientspecific procedure which has an enhanced recovery compared to END but is currently not widely offered to patients. There are exciting developments in the technology supporting SNB, improving the accuracy and ease of the procedure and opening up the technique to new tumour types. We describe our experiences in using a novel intraoperative navigation device for sentinel node retrieval and review other advances in SNB practice which have the potential to change the standard management for patients with early HNSCC.Keywords Sentinel node biopsy Á Freehand SPECT Á Head and neck squamous cell carcinoma Á Cervical metastasis Á Guided intraoperative scintigraphic tumour targeting (GOSTT)

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“…Aside from fhSPECT navigation, there are other possibilities for intraoperative sentinel node imaging such as portable gamma cameras [21][22][23][24] and fusion ultrasound/…”

Section: Emerging Developments For Sln Biopsy In Hn Cancermentioning

confidence: 99%

Role of intraoperative sentinel node imaging in head and neck cancer

Schilling

Corrado

Gnanasegaran

et al. 2015

Clin Transl Imaging

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“…This work was mainly aimed at assessing the capabilities of SFOV cameras; however, the phantom could equally be used with LFOV SPECT-CT cameras. Currently, there are many SFOV gamma imaging systems employed in intraoperative imaging [ 11 , 39 , 40 ]. However, anthropomorphic phantoms have still not been standardised or utilised to quantify the capability of these different systems to detect targeted tissues during intraoperative procedures such as SLN mapping.…”

Section: Discussionmentioning

confidence: 99%

Design and implementation of a prototype head and neck phantom for the performance evaluation of gamma imaging systems

et al. 2017

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BackgroundA prototype anthropomorphic head and neck phantom has been designed to simulate the adult head and neck anatomy including some internal organs and tissues of interest, such as thyroid gland and sentinel lymph nodes (SLNs). The design of the head and neck phantom includes an inner jig holding the simulated SLNs and thyroid gland. The thyroid gland structure was manufactured using three-dimensional (3D) printing taking into consideration the morphology and shape of a healthy adult thyroid gland.ResultThe head and neck phantom was employed to simulate a situation where there are four SLNs distributed at two different vertical levels and at two depths within the neck. Contrast to noise ratio (CNR) calculations were performed for the detected SLNs at an 80 mm distance between both pinhole collimators (0.5 and 1.0 mm diameters) and the surface of the head and neck phantom with a 100 s acquisition time. The recorded CNR values for the simulated SLNs are higher when the hybrid gamma camera (HGC) was fitted with the 1.0 mm diameter pinhole collimator. For instance, the recorded CNR values for the superficially simulated SLN (15 mm depth) containing 0.1 MBq of 99mTc using 0.5 and 1.0 mm diameter pinhole collimators are 6.48 and 16.42, respectively (~87% difference).Gamma and hybrid optical images were acquired using the HGC for the simulated thyroid gland. The count profiles through the middle of the simulated thyroid gland images provided by both pinhole collimators were obtained. The HGC could clearly differentiate the individual peaks of both thyroid lobes in the gamma image produced by the 0.5-mm pinhole collimator. In contrast, the recorded count profile for the acquired image using the 1.0-mm-diameter pinhole collimator showed broader peaks for both lobes, reflecting the degradation of the spatial resolution with increasing the diameter of the pinhole collimator.ConclusionsThis anthropomorphic head and neck phantom provides a valuable tool for assessing the imaging ability of gamma cameras used for imaging the head and neck region. The standardisation of test phantoms for SFOV gamma systems will provide an opportunity to collect data across various medical centres. The phantom described is cost effective, reproducible, flexible and anatomically representative.

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“…Moreover, they provide a visual real-time feedback when localizing SLNs and confirming their successful resection. For the most frequently used portable gamma camera (Sentinella, Oncovision, Valencia, Spain), promising results have been published for SLNB in HN malignancies [36][37][38][39] and urogenital cancers [40][41][42][43][44][45]. Portable gamma cameras can reliably detect deep-lying nodes and SLNs with only low tracer accumulation.…”

Section: Toward Intraoperative 3d Imagingmentioning

confidence: 99%

New technologies in radioguided surgery in complex anatomic areas

Bluemel

Herrmann

2016

Clin Transl Imaging

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Sentinel lymph node biopsy (SLNB) is the most common radioguided surgery procedure and standard of care for lymph node staging in clinically node-negative patients with melanoma and breast cancer. While SLNB has also emerged as a potential alternative to lymph node dissection for staging in patients with other solid malignancies, its use for this purpose has to date not been widely accepted owing to technical limitations in complex anatomic areas such as the head and neck and the pelvic region. However, new technologies have recently been developed to overcome these limitations. This review focuses on the new technologies that improve SLN localization in complex anatomic areas, including new diagnostic tracers ( 99m Tc-tilmanocept and hybrid tracers), preoperative SPECT/CT imaging, and scintigraphic threedimensional intraoperative imaging techniques.

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The added value of a portable gamma camera for intraoperative detection of sentinel lymph node in squamous cell carcinoma of the oral cavity: A case report

Cited by 5 publications

References 10 publications

Role of intraoperative sentinel node imaging in head and neck cancer

Role of intraoperative sentinel node imaging in head and neck cancer

Design and implementation of a prototype head and neck phantom for the performance evaluation of gamma imaging systems

New technologies in radioguided surgery in complex anatomic areas

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