The added value of rodent models in studying parental influence on offspring development: opportunities, limitations and future perspectives

Knop, Jelle; Joëls, Marian; Veen, Rixt van der

doi:10.1016/j.copsyc.2017.02.030

Cited by 22 publications

(17 citation statements)

References 72 publications

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“…To investigate exactly how ELA affects cognitive processing, rodent models are a valuable resource: they complement human studies by indepth and thorough investigations of otherwise hard-to-study mechanisms. In animal experiments, genetic and environmental influences can be more precisely controlled and experimentally varied than in humans (Knop et al, 2017). Furthermore, prospective designs are more feasible.…”

Section: Introductionmentioning

confidence: 99%

The behavioral phenotype of early life adversity: A 3-level meta-analysis of rodent studies

Bonapersona

Kentrop

Lissa

et al. 2019

Neuroscience & Biobehavioral Reviews

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The behavioral phenotype of early life adversity Bonapersona, V.; Kentrop, J.; Van Lissa, C. J.; van der Veen, R.; Joels, M.; Sarabdjitsingh, R. A. Citation for published version (APA): Bonapersona, V., Kentrop, J., Van Lissa, C. J., van der Veen, R., Joels, M., & Sarabdjitsingh, R. A. (2019). The behavioral phenotype of early life adversity: A 3-level meta-analysis of rodent studies. Neuroscience and Biobehavioral Reviews, 102, 299-307. https://doi.Altered cognitive performance is considered an intermediate phenotype mediating early life adversity (ELA) effects on later-life development of mental disorders, e.g. depression.Whereas most human studies are limited to correlational conclusions, rodent studies can prospectively investigate how ELA alters cognitive performance in several domains. Despite the volume of reports, there is no consensus on i) the behavioral domains being affected by ELA and ii) the extent of these effects. To test how ELA (here: aberrant maternal care) affects specific behavioral domains, we used a 3-level mixed-effect meta-analysis, and thoroughly explored heterogeneity with MetaForest, a novel machine-learning approach. Our results are based on > 400 independent experiments, involving ∼8600 animals. Especially in males, ELA promotes memory formation during stressful learning but impairs non-stressful learning. Furthermore, ELA increases anxiety-like and decreases social behavior. The ELA phenotype was strongest when i) combined with other negative experiences ("hits"); ii) in rats; iii) in ELA models of ∼10days duration. All data is easily accessible with MaBapp (https://osf.io/ra947/), allowing researchers to run tailor-made meta-analyses, thereby revealing the optimal choice of experimental protocols and study power.

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Section: Introductionmentioning

confidence: 99%

The behavioral phenotype of early life adversity: A 3-level meta-analysis of rodent studies

Bonapersona

Kentrop

Lissa

et al. 2019

Neuroscience & Biobehavioral Reviews

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“…Maternal care, or lack thereof, can also lead to longterm changes in neuroanatomy visible even in adulthood in humans and rodents (25). Previous studies from our group have demonstrated long-lasting effects to maternal care on chicken brain; maternal care to layer chicks in early life caused increased expression of arginine vasotocin (AVT; a vasopressin ortholog found in birds, reptiles and fish) in the medial preoptic area of the hypothalamus (26) and alterations in differences of cell size between the two hemispheres in the hippocampus (27) when brains of adult animals were examined.…”

Section: Introductionmentioning

confidence: 99%

Effects of Dark Brooder Rearing and Age on Hypothalamic Vasotocin and Feather Corticosterone Levels in Laying Hens

et al. 2020

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Chickens cannot independently thermoregulate at hatch and lack opportunity to behaviorally thermoregulate with a hen in the egg layer industry, thus barns are heated to thermoneutral temperatures. Dark brooders are low-energy-consuming hot plates, which may be environmentally advantageous while providing welfare-enhancing aspects of maternal care (i.e., shelter and separation of active and inactive individuals). Dark brooder use has been demonstrated to decrease injurious pecking and mortality well into the production period of layers. To further understand hen development around lay onset and effects of dark brooders on the brain and HPA-axis, we examined effects of rearing with dark brooders on expression of vasotocin (AVT) in the hypothalamus and corticosterone (CORT) in the feathers of in total 48 layer Isa Warren hens at 16 w and 28 w of age (n = 12 per age and treatment). An age-dependent decreased number of AVT-positive neurons was seen in the medial preoptic area, medial preoptic nucleus, paraventricular nucleus, rostral part (prepeduncular hypothalamus), and lateral preoptic area. Trends to effects of brooder rearing were found in both anteromedial preoptic nucleus and supraoptic nucleus, with dark brooder reared animals showing higher mean counts of AVT-positive neurons in both areas. No interactions between brooder raising and age were observed in AVT-positive neuron count. CORT levels were higher in primary wing feathers from 28 week old hens than in those from 16 week hens. No main effects of rearing with dark brooders or interactions between age and treatment were found on CORT levels. The age-dependent effects seen in the hypothalamus and CORT aids in further understanding of the development of chickens around puberty. The use of brooders tended to increase AVT expression in the anteromedial preoptic nucleus and supraoptic nucleus, an indication that dark brooder rearing may affect physiological responses regulated by these areas. The lack of effect of dark brooders on CORT in feathers is at the least an indication that the use of dark brooders is not stressful; in combination with the benefits of dark brooders on injurious pecking, fearfulness and early mortality, this pleads for the use of dark brooders in on-farm situations.

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“…Experimental manipulations that induce disordered caregiving or maternal neglect in rodents, such as maternal separation, have been utilized for decades and are still major tools in our investigations of effects on offspring (see below, also [23], this issue) [24]. However, these experimental manipulations do not shed light on naturally occurring neglect or abuse.…”

Section: Neurobiology Of Motheringmentioning

confidence: 99%

Parenting in animals

Bales

2017

Current Opinion in Psychology

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The study of parenting in animals has allowed us to come to a better understanding of the neural and physiological mechanisms that underlie mammalian parental behavior. The long-term effects of parenting (and parental abuse or neglect) on offspring, and the neurobiological changes that underlie those changes, have also been best studied in animal models. Our greater experimental control and ability to directly manipulate neural and hormonal systems, as well as the environment of the subjects, will ensure that animal models remain important in the study of parenting; while in the future, the great variety of parental caregiving systems displayed by animals should be more thoroughly explored. Most importantly, cross-talk between animal and human subjects research should be promoted.

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The added value of rodent models in studying parental influence on offspring development: opportunities, limitations and future perspectives

Cited by 22 publications

References 72 publications

The behavioral phenotype of early life adversity: A 3-level meta-analysis of rodent studies

The behavioral phenotype of early life adversity: A 3-level meta-analysis of rodent studies

Effects of Dark Brooder Rearing and Age on Hypothalamic Vasotocin and Feather Corticosterone Levels in Laying Hens

Parenting in animals

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