The additive clinical value of combined thyroglobulin and antithyroglobulin antibody measurements to define persistent and recurrent disease in patients with differentiated thyroid cancer

Abstract

Combined Tg-TgAb values were found more useful than only Tg for recurrent and persistent diseases. Combined Tg and TgAb measurements seemed to be a useful marker.

Recurrence detection in differentiated thyroid cancer patients with elevated serum level of antithyroglobulin antibody: special emphasis on using 18F‐FDG PET/CT

“…Chung et al considered a serum TgAb level below 100 U/ml as negative, and found elevated TgAb levels in 22AE6% of DTC patients after ablation. 10,15 Recently, Aras et al 17 reported that the optimal threshold value for TgAb was 27AE8 IU/ml. TgAbs remained detectable in 44AE2% at 6-12 months after therapy.…”

Management of Thyroid Peroxidase Antibody Euthyroid Women in Pregnancy: Comparison of the American Thyroid Association and the Endocrine Society Guidelines

“…This occurrence of TgAb is uncorrelated with abnormal TSH levels, which indicates that it may not be necessary to test for TgAb and TPOAb in the general thyroid autoimmunity screening, as TPOAb testing alone seems sufficient [10]. In those individuals with indications of autoimmune thyroid disease (AITD), however, there is evidence that testing for both TPOAb and TgAb is beneficial [11, 12]. We only refer to TPOAb in this analysis.…”

Serum midkine as a surrogate biomarker for metastatic prediction in differentiated thyroid cancer patients with positive thyroglobulin antibody

“…Several attempts have been made to address this issue. For instance, Aras et al 12. showed that combined Tg and TgAb measurements were more informative than Tg only for recurrent and persistent DTC patients.…”