The additive prognostic value of wall motion abnormalities and coronary flow reserve during dipyridamole stress echo

Abstract

In patients with known or suspected CAD, DET result by wall motion criteria and CFR are additive and complementary for the identification of patients at risk of experiencing hard events.

Coronary flow velocity reserve predicts survival in non-diabetic patients

“…In a recent study, DM and CFR were independently predictive of cardiovascular survival in patients with known or suspected CAD [2]. The additive prognostic value of simultaneously evaluated CFR and wall motion abnormalities [3,[21][22][23][24], aortic distensibility indices [25], or grade of AA [26] was also demonstrated. Moreover, CFR was found to be predictive for future events in hypertensives [27], AS [6], dilated [28][29][30] and hypertrophic cardiomyopathies [5,31], in renal transplant recipients [32] and after heart transplantation [33], as well.…”

“…The prognostic role of echocardiography-derived CFR is widely examined in patients with suspected or known CAD [2][3][4][7][8][9][16][17][18][19][20][21][22][23][24][25]. CFR has a prognostic significance on cardiovascular outcome not only in patients with significant CAD [16], but also in subjects with intermediate (50 to 75%) LAD stenosis [17,18] or angiographically normal or near-normal coronary arteries [4,8,19].…”

Models of Major Adverse Cardiac Event Risk Using Results of Exercise Stress Echocardiography With Noninvasive Coronary Artery Flow Assessment in Patients With Ischemic Heart Disease

“…У пациентов с предполагаемой или диагностированной ИБС на крупной выборке бо-лее 1100 человек, направленных с диагностической це-лью для проведения теста с дипиридамолом, было про-демонстрировано дополнительное прогностическое значение коронарного резерва ПМЖА для предсказа-ния неблагоприятных исходов в течение 3 лет. Это было выявлено как для положительных, так и для отрица-тельных (неишемических) тестов [16]. Действительно, коронарный резерв ПМЖА<1,9-2,0 предопределяет бо-лее высокую годовую летальность вне зависимости от возраста, пола, фракции выброса, наличия ИБС в анамнезе на момент теста, диабета и АГ.…”

Coronary microvascular dysfunction due to essential thrombocythemia and policythemia vera: The missing piece in the puzzle of their increased cardiovascular risk?

“…All our patients with PV and ET had a negative stress-echo, which indirectly supports the absence of significant coronary artery stenosis explaining their abnormal CFR. However, even patients with negative stress echocardiographic test should de considered at risk of spontaneous events (death and worsening of clinical status) [30][31][32]. These data are true for patients with CAD but it is well known that reduced CFR in patients without CAD is still an independent negative prognostic factors [30,33].…”