“…With the early treatment of gonorrhoea with penicillin using amorphous penicillins and crystalline penicillin G (for example, by Heller 1946 ; Lakaye 1946 ; Fawkes 1949) cure rates exceeding 90 per cent were obtained with small doses of only 100,000 to 300,000 units spread over short periods of up to 12 hours. For a time some clinicians (for example, Turanova (1948) in Soviet Russia, combined sulphonamides with penicillin but the results obtained with penicillin alone were so good that it was difficult to show that combined treatment was superior.…”