The adhesion molecules NCAM, HCAM, PECAM‐1 and ICAM‐1 in normal salivary gland tissues and salivary gland malignancies

Perschbacher, Kristina; Jackson-Boeters, Linda; Daley, Tom D.

doi:10.1111/j.0904-2512.2004.00027.x

Cited by 14 publications

(11 citation statements)

References 22 publications

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“…It has been reported that NCAM upregulation in cancer cells facilitates the migration of the cancer cells towards the nerves and promotes perineural spread in tumours including in bile duct cancer [17], gallbladder cancer [18], head and neck squamous cell carcinomas [19] and rectal cancer [20]. On the other hand, it is unlikely that NCAM plays an important role in neurotropism in tumours such as pancreatic cancer [21] or salivary gland malignancies [22]. Li et al [23] reported that NCAM expression is upregulated in nerves with PNI compared with nerves without PNI in prostate cancer.…”

Section: Discussionmentioning

confidence: 99%

Growth pattern in the muscular layer reflects the biological behaviour of colorectal cancer

et al. 2009

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Section: Discussionmentioning

confidence: 99%

Growth pattern in the muscular layer reflects the biological behaviour of colorectal cancer

et al. 2009

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“…Literature on NCAM expression in adenoid cystic carcinoma is rare. In clinical reports which can be found through Medline, the expression of NCAM in adenoid cystic carcinoma has been reported to be 89, 100, 31 and 25% (11)(12)(13)(14). Gandour-Edwards et al investigated 18 cases in which adenoid cystic carcinoma invaded the skull base.…”

Section: Discussionmentioning

confidence: 99%

Expression of neural cell adhesion molecule in salivary adenoid cystic carcinoma and its correlation with perineural invasion

Shang

Sheng²,

Wang³

et al. 2007

Oncol Rep

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The expression of neural cell adhesion molecule (NCAM) was analyzed in immunohistochemical preparations from adenoid cystic carcinoma. The goal was to evaluate whether NCAM expression could be used as a biological marker for the perineural invasion of adenoid cystic carcinoma in the head and neck. The presence of perineural invasion and NCAM expression was evaluated in samples from 49 patients. Perineural invasion was identified in 33 of them (67%). A high incidence of perineural invasion was found in adenoid cystic carcinoma in the parotid, hard palate, maxillary sinus and oral cavity. Positive NCAM staining was observed in 28 of 49 patients (57%). Of the 28 patients with NCAM staining, perineural invasion was identified in 24 (86%). In contrast, only 9 (43%) of the 21 tumors without NCAM staining had perineural invasion. The difference in NCAM expression between cases with and without perineural invasion was statistically significant (p<0.01). When positive NCAM staining was used to estimate the presence of perineural invasion, the sensitivity was 73 and the specificity 75%. Histopathologic nodal involvement was found in 6 of 18 cases in which neck dissection had been performed. All 6 cases displayed positive NCAM staining, and 5 displayed perineural invasion in the primary adenoid cystic carcinoma. In conclusion, NCAM expression can, to a certain extent, be used as a predictor of perineural invasion in adenoid cystic carcinoma. Moreover, lymph node metastases could serve as a clinical indicator for perineural invasion and for NCAM expression.

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“…NCAM is expressed by peripheral nerve sheath cells and its expression has been reported in 31–100% of cases of ACC, (112–115) . However, no correlation was found between the intensity of staining and either perineural invasion or recurrence (112, 114) . HCAM, PECAM-1 , and ICAM-1 have also been studied; however, no correlation was found between level of expression and invasion or recurrence in any of these molecules.…”

Section: Tumor Suppressor Genesmentioning

confidence: 99%

“…Expression patterns of HCAM and ICAM-1 were similar to those of normal salivary gland tissue; alteration in the expression of these proteins does not appear to occur with malignant transformation. One case of ACC with a poor clinical outcome showed weak PECAM-1 staining of tumor cells, but further studies are needed to elucidate the role of PECAM-1 in ACC progression (112) .…”

Section: Tumor Suppressor Genesmentioning

confidence: 99%

Molecular biology of adenoid cystic carcinoma

et al. 2011

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Background Adenoid cystic carcinoma (ACC) is an unusual salivary gland malignancy that remains poorly understood. Standard treatment, including surgery with postoperative radiation therapy have attained reasonable local control rates, but the propensity for distant metastases has limited any improvement in survival over time. Our understanding of the molecular mechanisms driving adenoid cystic carcinoma is quite rudimentary, due to the infrequent nature of its occurrence. Methods An extensive literature review was performed on salivary gland adenoid cystic carcinoma and basic science research findings. Results This review highlights many findings that are emerging about the carcinogenesis of ACC including cytogenetics, tumor suppressor genes, oncogenes, epigenetic alterations, mitochondrial alterations, and biomarker studies. Conclusions While there have been many discoveries, much still remains unknown about this rare malignancy.

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The adhesion molecules NCAM, HCAM, PECAM‐1 and ICAM‐1 in normal salivary gland tissues and salivary gland malignancies

Abstract: Immunohistochemical demonstration of NCAM, HCAM, and ICAM-1 is not related to perineural invasion or tumor behavior. PECAM-1 expression was related to vascular invasion and poor patient prognosis in three cases.

Cited by 14 publications

References 22 publications

Growth pattern in the muscular layer reflects the biological behaviour of colorectal cancer

Growth pattern in the muscular layer reflects the biological behaviour of colorectal cancer

Expression of neural cell adhesion molecule in salivary adenoid cystic carcinoma and its correlation with perineural invasion

Molecular biology of adenoid cystic carcinoma

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