The Adhesiveness of Blood Platelets in Thromboembolism and Hemorrhagic Disorders: I. Measurement of Platelet Adhesiveness by the Glass-Wool Filter

Moolten, Sylvan E.; Vroman, Leo

doi:10.1093/ajcp/19.8.701

Cited by 91 publications

(16 citation statements)

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“…Moolten et al [83] observed that alimentary Iipemia was associated with increased platelet stickiness as measured by the glass wool braid technique [84]. They offered normal, atherosclerotic and diabetic volunteers a low-fat diet or a diet containing 36 g animal fat (cream and eggs) or maize oil.…”

Section: Single Loading O F Fatmentioning

confidence: 99%

Dietary Fats and Arterial Thrombosis

Hornstra¹

1973

Pathophysiol Haemos Thromb

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Section: Single Loading O F Fatmentioning

confidence: 99%

Dietary Fats and Arterial Thrombosis

Hornstra¹

1973

Pathophysiol Haemos Thromb

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“…Wright [31] was the first who introduced a method for the measure ment of the PAd; she used anticoagulated blood placed in a glass flask which was rotated; M oolten and Vroman [16] used a column of glass wool as contact surface instead of the flask. In 1960 H ellem [9] re placed the column of glass wool by one of glass beads (glass bead filter) and used a syringe pump by means of which anticoagulated blood was pushed through the filter; O 'Brien's technique [20] differs from that of Hellem's mainly because blood without anticoagulant is used.…”

Section: Introductionmentioning

confidence: 99%

The Value of the Platelet Adhesiveness Test in the Assessment of Abnormalities of Platelet Function

Papayannis¹,

Israëls²

1971

Acta Haematol

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A slightly modified Salzman technique for platelet adhesiveness is described and a normal range of 32% to 65% has been established. There is no variation with age or sex. But investigation shows that this type of technique is sensitive to variations in the packed-red-cell volume of the blood, and that for comparable estimates the PCV must be between 33% and 46%. The platelet adhesiveness test gives a low result in von Willebrand’s disease and low results have also been found in 4 syndromes characterized by defective platelet aggregation. The reasons for correlation of platelet adhesiveness and platelet aggregation, the limitations of the use of the platelet adhesiveness as a screening test, and the possible role of a plasma factor are discussed.

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“…effect on platelet aggregation should be considered, especially during shock or post-operative conditions, where a state of in creased platelet adhesiveness has been described [Moolten,10].…”

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confidence: 99%