The adipokine visfatin induces tissue factor expression in human coronary artery endothelial cells

Plasma visfatin levels are associated with major adverse cardiovascular events in patients with acute ST-elevation myocardial infarction

“…A previous study also indicated that visfatin induces TF-mRNA transcription and de novo synthesis of functionally active TF in human coronary artery endothelial cells in culture [13]. These phenomena appear to be regulated through activation of NF-κB pathway [13]. This study gives a newer point of view on the potential role of visfatin in the pathophysiology of ACS.…”

“…Visfatin can promote luded adjus fatin, heart a, Killip cla ct. RR, relat stment for age, sevascular smooth muscle inflammation and is associated with a potential role in vascular dysfunction [29] and carotid atherosclerosis [17]. A previous study also indicated that visfatin induces TF-mRNA transcription and de novo synthesis of functionally active TF in human coronary artery endothelial cells in culture [13]. These phenomena appear to be regulated through activation of NF-κB pathway [13].…”

“…Previous reports have suggested that visfatin is an inflammatory protein associated with plaque destabilization, atherosclerosis, and acute coronary syndrome (ACS) [11,12]. In addition, previous evidence has indicated that visfatin, at doses measurable in ACS patient plasma, induces a procoagulant phenotype in human coronary endothelial cells by promoting tissue factor (TF) expression and suggested that visfatin might play an active role in atherothrombotic disease [13]. Furthermore, our previous studies showed that plasma visfatin levels are associated with infarctrelated artery (IRA) occlusion and that increased plasma visfatin may be closely related to the degree of myocardial damage [14,15].…”

The Relationship between Plasma Visfatin/Nampt and Type 2 Diabetes, Obesity, Insulin Resistance, and Cardiovascular Disease

“…An important study by Cirillo and colleagues showed that Visfatin induced tissue factor expression in human coronary artery endothelial cells (HCAECs). 53 The authors stimulated HCAECs with Visfatin concentrations that are comparable to levels found in patients with acute coronary syndromes and demonstrated that Visfatin promoted the expression of tissue factor, inducing a procoagulant phenotype in human coronary endothelial cells through the activation of nuclear factor (NF) kB. 53 In an editorial accompanying the same article by Cirillo and colleagues, Halvorsen and colleagues highlighted the complex role of Visfatin in atherosclerosis as it has been shown to mediate both adaptive and maladaptive effects in atherosclerosis, depending on its molecular form.…”

“…53 The authors stimulated HCAECs with Visfatin concentrations that are comparable to levels found in patients with acute coronary syndromes and demonstrated that Visfatin promoted the expression of tissue factor, inducing a procoagulant phenotype in human coronary endothelial cells through the activation of nuclear factor (NF) kB. 53 In an editorial accompanying the same article by Cirillo and colleagues, Halvorsen and colleagues highlighted the complex role of Visfatin in atherosclerosis as it has been shown to mediate both adaptive and maladaptive effects in atherosclerosis, depending on its molecular form. 54 The authors referred to the challenges facing researchers working on Visfatin and raised important research questions with regards to whether extracellular Visfatin/Nampt activity is mediated through a receptor, through enzymatic activity or non-enzymatic.…”