The Adjuvant Effect of Sophy ¥-Glucan to the Antibody Response in Poultry Immunized by the Avian Influenza A H5N1 and H5N2 Vaccines

Le, Thanh Hoa; Le, Tran Binh; Doan, Thanh Huong Thi; Quyền, Đồng Văn; Le, Kim Xuyen Thi; Pham, Viet Cuong; Nagataki, Mitsuru; Nomura, Haruka; Ikeue, Yasunori; Watanabe, Yuji; Agatsuma, Takeshi

doi:10.4014/jmb.1011.11024

Cited by 30 publications

(17 citation statements)

References 25 publications

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“…NK cell activity was significantly increased by this beta glucan in patients with Leishmania amazonensis infection ( 50 ). This beta glucan had regulatory or enhancing properties on poultry non-specific cellular immunity in a study on Peking ducks ( 51 ) and may enhance the immune response to avian influenza A H5 vaccine ( 52 ). This AFO-202 beta glucan increased the NK cell and macrophage counts in cancer patients and elderly patients ( 53 ).…”

Section: Preventive and Therapeutic Nutritional Interventions For Covmentioning

confidence: 99%

Role of Immune Dysregulation in Increased Mortality Among a Specific Subset of COVID-19 Patients and Immune-Enhancement Strategies for Combatting Through Nutritional Supplements

et al. 2020

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Section: Preventive and Therapeutic Nutritional Interventions For Covmentioning

confidence: 99%

Role of Immune Dysregulation in Increased Mortality Among a Specific Subset of COVID-19 Patients and Immune-Enhancement Strategies for Combatting Through Nutritional Supplements

et al. 2020

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“…β-glucans are structural components of cell walls in many different sources including bacteria, fungi, yeast, and algae. Some β-glucans have been shown to improve gut health ( Shao et al., 2013 ) in poultry subjected to a bacterial challenge, to increase macrophage function ( Qureshi, 2003 ), to increase antibody titers after a vaccination ( Le et al., 2011 ), and to function as an anti-inflammatory immunomodulator ( Cox et al., 2010a ). However, molecular weight and branching degree can influence the immune response of β-glucan via the production of cytokines and the enhancement of phagocytic activity and antibactericidal activity.…”

Section: Introductionmentioning

confidence: 99%

Effect of dietary β-1,3-glucan supplementation and heat stress on growth performance, nutrient digestibility, meat quality, organ weight, ileum microbiota, and immunity in broilers

Zhang

Ou²,

Luo³

et al. 2020

Poultry Science

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The objective of this study was to determine the effect of dietary β-1,3-glucan supplementation and heat stress ( HS ) on growth performance, nutrient digestibility, meat quality, organ weight, ileum microbiota, and immunity in broiler. A total of 1,440 1-day-old Ross 308 male chicks with an average initial BW of 43.06 ± 1.94 g were sorted into 6 (2 × 3) treatments, 14 replications per treatment. This trail included 2 factors: the dosage of β-1,3-glucan (0, 100 g/T, and 200 g/T) and feeding condition (HS and normal). During the whole trial, significant impacts were observed in BW gain, feed intake，feed conversion rate, and the digestibility of DM and energy between normal treatments and HS treatments ( P < 0.05). From day 21 to 35, HS-challenged birds fed the diet with 200 g/T β-1,3-glucan had a lower feed conversion rate than those fed the diet with 0 or 100 g/T β-1,3-glucan ( P < 0.05). Moreover, the HS-exposed birds that fed the diet with β-1,3-glucan indicated a greater energy digestibility than those fed the nontreatment diet ( P < 0.05). Besides, β-1,3-glucan supplementation could elevate meat pH of all birds and decrease cooking loss significantly of HS-exposed birds ( P < 0.05). The HS birds fed the β-1,3-glucan diet obtained a reduced amount of Escherichia coli in the ileum than those fed the nontreatment diet ( P < 0.05). Besides, β-1,3-glucan supplementation lowered the level of tumor necrosis factor-α in HS-exposed birds significantly ( P < 0.05). These results indicated 100 and 200 g/T β-1,3-glucan supplementation, under HS condition or not, can increase growth performance without a negative response on immunity. Under HS condition, the addition of β-1,3-glucan at dosage from 100 to 200 g/T in the diet can increase energy digestibility, decrease cooking loss, reduce E. coli mount in the ileum, and the tumor necrosis factor-α concentration.

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“…The immuno-modulatory process initiates when the βglucan binds to cell surface receptors of macrophages, lymphocytes and neutrophils (Chen and Seviour, 2007;Guo et al, 2003). β-glucan activates B-lymphocytes and macrophages through dectin-1, CR3, lactosylceramide, scavenger receptors and Toll-like receptors (Le et al, 2011;Taylor et al, 2002), modulating the immune system and inducing the production of cytokines (Cheng et al, 2004).…”

Section: Nutritional Interventionsmentioning

confidence: 99%

“…In broilers, β-glucan has been shown to be an excellent adjuvant for the avian influenza H5 subtype vaccine, enhancing the vaccine immunogenicity (Le et al, 2011). Mannan-oligosaccharide-bound pathogens were prevented from attaching to intestinal mannose residues (Spring et al, 2000), and mannose blocked the colonization of intestinal pathogens, such as Salmonella spp.…”

Section: Effect Of Interventions On Intestinal Adhesion Of Pathogensmentioning

confidence: 99%

Effect of nutritional interventions with quercetin, oat hulls, β-glucans, lysozyme, and fish oil on immune competence related parameters of adult broiler

Krimpen¹,

Torki²,

Schokker³

et al. 2016

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2015. Effect of nutritional interventions with quercetin, oat hulls, β-glucans, lysozyme or fish oil on immune competence related parameters of adult broilers. Wageningen Livestock Research Report 977.The purpose of this experiment was to evaluate the effects of five nutritional interventions, provided during d 14 -28, including inclusion of a plant extract (quercetin); an insoluble fiber (oat hulls); a prebiotic (β-glucan); an anti-microbial protein (lysozyme), and ω-3 fatty acids from fish oil, on growth performance, composition of the intestinal microbiota, and morphology and gene expression of small intestine of broilers. Despite the different types of interventions, parameters related to immune competence were only marginally affected by the tested products. It seemed that in this study inclusion of oat hulls, and probably β-glucans, had perspective to improve immune competence. It is recommended to revaluate some of the tested interventions, especially dietary inclusion of oat hulls and β-glucans, in broilers starting from day-old onward.This report can be downloaded for free at http://dx. References 37Appendix 1 Calculated composition of the diets 48 Appendix 2 Calculated composition of the starter and finisher diets 49 Appendix 3 Chemical and nutritional composition of the rapeseed extract used in the present experiment comparing with canola meal (Khajali and Slominski, 2012) 50Limited effects of nutritional interventions were observed on gene expression of the gut tissue, and the genes differently expressed between dietary treatments do not seem to be directly involved in immune related processes. Despite the different types of interventions, parameters related to immune competence were only marginally affected by the tested products. It seemed that in this study inclusion of oat hulls, and probably β-glucans, had perspective to improve immune competence. It is recommended to revaluate some of the tested interventions, especially dietary inclusion of oat hulls and β-glucans, in broilers starting from day-old onward.

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The Adjuvant Effect of Sophy ¥-Glucan to the Antibody Response in Poultry Immunized by the Avian Influenza A H5N1 and H5N2 Vaccines

Cited by 30 publications

References 25 publications

Role of Immune Dysregulation in Increased Mortality Among a Specific Subset of COVID-19 Patients and Immune-Enhancement Strategies for Combatting Through Nutritional Supplements

Role of Immune Dysregulation in Increased Mortality Among a Specific Subset of COVID-19 Patients and Immune-Enhancement Strategies for Combatting Through Nutritional Supplements

Effect of dietary β-1,3-glucan supplementation and heat stress on growth performance, nutrient digestibility, meat quality, organ weight, ileum microbiota, and immunity in broilers

Effect of nutritional interventions with quercetin, oat hulls, β-glucans, lysozyme, and fish oil on immune competence related parameters of adult broiler

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