The Administration of Adrenocorticotrophic Hormone to Normal Human Subjects. The Effect of the Leucocytes in the Blood and on Circulating Antibody Levels

Effect of Cortisone on Acute Streptococcal Infections and Post-Streptococcal Complications 1

“…The decrease in percentage of treated patients having leucocyte counts greater than 10,000 on the second day (Table IV) can possibly be explained by the fact that on this day most of the determinations were made about one hour after treatment. This drop in total leucocyte count immediately following the injection of ACTH and adrenal cortical extracts has been described (1,20,21). The remaining counts were taken about 13 hours following the previous injection.…”

Effect of Hydrocortisone on Immunoglobulin Synthesis and Secretion by Human Peripheral Lymphocytes <i>in vitro</i>

“…It has already been noted [3][4][5][6] that studies of the effects of adrenal corticosteroids on the humoral immune response of humans have been inconclusive, but in general corticosteroids did not seem to suppress a secondary immune response in man. Recently, it has been reported [17] that (alternate day) therapy with prednisone was associated with an en hanced primary response (at 2 weeks) in asthmatic children immunized with keyhole limpet hcmocyanin (KLH).…”

“…Murine animals and rabbits are among the species most susceptible to the lymphocytolytic effects of steroids, whereas the lymphocytes of man are more refractory [2]. While corticosteroids have been reported not to suppress a humoral immune response in man [3][4][5][6], their effect on the in vitro immune response has received little attention in any species. However, recent evidence indi cates that hydrocortisone can replace serum in rabbit lymph node tissue cultures for the initiation of a secondary immune response in vitro [7][8].…”

The Influence of Cortisone Upon the Diurnal Rhythm of Renal Excretory Function

“…Finally, a patient with Addison's disease has been studied while maintained on desoxycorticosterone acetate (1.25 mg. intramuscularly at 6 a.m. and 6 p.m.) and cortisone (6.25 mg. orally at 6 a.m. and 6 p.m.) (85). When he remained at bed rest and took identical food and fluid every six hours day and night, the 2The existence of such an adrenocortical rhythm in man is suggested by observations that the renal excretion of 17-ketosteroids (75)(76)(77)(78)(79), neutral reducing lipids (78), and uric acid (8,36,37) is less at night than during the day, as well as by the fact that the numbers of circulating lymphocytes (80) and eosinophils (81)(82)(83) (32). Alterations in the total daily excretion of water and solutes such as urea and phosphate related to increased food intake and protein catabolism during cortisone administration might induce changes in the diurnal excretory pattern.…”