The administration of rescue medication to children with prolonged acute convulsive seizures in the community: What happens in practice?

Wait, Suzanne; Lagae, Lieven; Arzimanoglou, Alexis; Beghi, Ettore; Bennett, Christine; Cross, J. Helen; Mifsud, Janet; Schmidt, Dieter; Harvey, Gordon

doi:10.1016/j.ejpn.2012.07.002

Cited by 42 publications

(34 citation statements)

References 20 publications

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“…The attitude to call the emergency services may reflect the policy of several schools (in Italy and other countries), which require calling an ambulance for every prolonged convulsive seizure that occurs at school, potentially causing treatment delays and subsequent complications for the child [25,26]. Current guidelines in several European countries (including Italy) recommend immediate treatment of children with such seizures to prevent progression to status epilepticus and neurological morbidity [27]. As children are unconscious during prolonged convulsive seizures, the administration of rescue medication depends on the presence of a teacher or other members of staff trained and able to administer such treatment.…”

Section: Discussionmentioning

confidence: 98%

An educational campaign toward epilepsy among Italian primary school teachers

Mecarelli

Messina

Capovilla

et al. 2014

Epilepsy & Behavior

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Section: Discussionmentioning

confidence: 98%

An educational campaign toward epilepsy among Italian primary school teachers

Mecarelli

Messina

Capovilla

et al. 2014

Epilepsy & Behavior

Self Cite

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“…Rectal diazepam provided a much needed treatment option for outof-hospital prolonged seizures and seizure clusters, but the route of administration may be problematic in social settings and fear of liability seems to be a critical issue for many schools and teachers [3]. Several alternative routes for acute administration of benzodiazepines are being explored.…”

Section: Introductionmentioning

confidence: 99%

Intranasal therapies for acute seizures

Kälviäinen

2015

Epilepsy & Behavior

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“…In most European countries, no clear guidance is available for the treatment of PACS outside of the hospital setting and no clear guidance is provided for caregivers [13,14]. …”

Section: Introductionmentioning

confidence: 99%

A comparison of the cost-effectiveness of treatment of prolonged acute convulsive epileptic seizures in children across Europe

et al. 2014

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In the majority of children and adolescents with epilepsy, optimal drug therapy adequately controls their condition. However, among the remaining patients who are still uncontrolled despite mono-, bi- or tri-therapy with chronic anti-epileptic treatment, a rescue medication is required. In Western Europe, the licensed medications available for first-line treatment of prolonged acute convulsive seizures (PACS) vary widely, and so comparators for clinical and economic evaluation are not consistent. No European guidelines currently exist for the treatment of PACS in children and adolescents and limited evidence is available for the effectiveness of treatments in the community setting. The authors present cost-effectiveness data for BUCCOLAM® (midazolam oromucosal solution) for the treatment of PACS in children and adolescents in the context of the treatment pathway in seven European countries in patients from 6 months to 18 years. For each country, the health economic model consisted of a decision tree, with decision nodes informed by clinical data and expert opinion obtained via a Delphi methodology. The events modelled are those associated with a patient experiencing a seizure in the community setting. The model assessed the likelihood of medication being administered successfully and of seizure cessation. The associated resource use was also modelled, and ambulance call-outs and hospitalisations were considered. The patient’s quality of life was estimated by clinicians, who completed a five-level EuroQol five dimensions questionnaire from the perspective of a child or adolescent suffering a seizure. Despite differences in current therapy, treatment patterns and healthcare costs in all countries assessed, BUCCOLAM was shown to be cost saving and offered increased health-related benefits for patients in the treatment of PACS compared with the current local standard of care.

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The administration of rescue medication to children with prolonged acute convulsive seizures in the community: What happens in practice?

Cited by 42 publications

References 20 publications

An educational campaign toward epilepsy among Italian primary school teachers

An educational campaign toward epilepsy among Italian primary school teachers

Intranasal therapies for acute seizures

A comparison of the cost-effectiveness of treatment of prolonged acute convulsive epileptic seizures in children across Europe

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