The administration of surfactant decreased oxidative stress in lungs of mice exposed to cigarette smoke

Machado, Dafne Fernandes; Campos, Keila Karine Duarte; Silva, Natália Pereira da; Ramos, Camila de Oliveira; Cangussú, Sílvia Dantas; Costa, Guilherme de Paula; Talvani, André; Bezerra, Frank Silva

doi:10.1016/j.intimp.2017.11.023

Cited by 8 publications

(4 citation statements)

References 52 publications

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“…6 We observed that exogenous surfactant administration reduced the oxidative damage in the lung parenchyma in animals submitted to MV in both supine and prone position. Our results corroborate previous findings demonstrating an antioxidant action of exogenous surfactant in different experimental models, 24,58 thus reinforcing the effectiveness of exogenous surfactant pre-treatment.…”

Section: Discussionsupporting

confidence: 92%

Exogenous surfactant reduces inflammation and redox imbalance in rats under prone or supine mechanical ventilation

Souza

Diedrich

Machado-Junior

et al. 2023

Exp Biol Med (Maywood)

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Mechanical ventilation (MV) is a lifesaving therapy for patients with acute or chronic respiratory failure. Despite, it can also cause lung injury by inducing or worsening inflammatory responses and oxidative stress. Several clinical approaches have protective effects on the lungs, including the prone position and exogenous surfactant; however, few studies have evaluated the association between the two strategies, especially in individuals without previous lung injury. We tested the hypothesis that the effects of the homogenization in lung aeration caused by the prone position in association with the anti-inflammatory properties of exogenous surfactant pre-treatment could have a cumulative protective effect against ventilator-induced lung injury. Therefore, Wistar rats were divided into four experimental groups: Mechanical Ventilation in Supine Position (MVSP), Mechanical Ventilation in Prone position (MVPP), Mechanical Ventilation in Supine Position + surfactant (MVSPS), and Mechanical Ventilation in Prone Position + Surfactant (MVPPS). The intranasal instillation of a porcine surfactant (Curosurf®) was performed in the animals of MVSPS and MVPPS 1 h before the MV, all the rats were subjected to MV for 1 h. The prone position in association with surfactant decreased mRNA expression levels of pro-inflammatory cytokines in ventilated animals compared to the supine position; in addition, the NfκB was lower in MVPP, MVSPS and MVPPS when compared to MVSP. However, it had no effects on oxidative stress caused by MV. Pre-treatment with exogenous surfactant was more efficient in promoting lung protection than the prone position, as it also reduced oxidative damage in the lung parenchyma. Nevertheless, the surfactant did not cause additional improvements in most parameters that were also improved by the prone position. Our results indicate that the pre-treatment with exogenous surfactant, regardless of the position adopted in mechanical ventilation, preserves the original lung histoarchitecture, reduces redox imbalance, and reduces acute inflammatory responses caused by mechanical ventilation in healthy adult Wistar rats.

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Section: Discussionsupporting

confidence: 92%

Exogenous surfactant reduces inflammation and redox imbalance in rats under prone or supine mechanical ventilation

Souza

Diedrich

Machado-Junior

et al. 2023

Exp Biol Med (Maywood)

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“…The ES (The CUROSURF brand surfactant (Chiesi Farmaceutici S.p.A., Parma, Italy) was administered by intranasal instillation 12 h before exposure to hyperoxia in only one dose of 2.0 mL/kg/day (50 μL) [4].…”

Section: Methodsmentioning

confidence: 99%

“…Important concerns have been raised, however, regarding the practical administration of surfactant and its ability to reach the alveoli [3]. Recently, our research team showed that ES administration decreased oxidative stress in the lungs of mice exposed to cigarette smoke [4].…”

Section: Introductionmentioning

confidence: 99%

Exogenous surfactant prevents hyperoxia-induced lung injury in adult mice

Bezerra

Ramos

Castro

et al. 2019

ICMx

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Background In addition to the risk of developing ventilator-induced lung injury, patients with ARDS are at risk of developing hyperoxic injury due the supra-physiological oxygen supplementation clinically required to reverse hypoxemia. Alterations of endogenous surfactant system participate in the pulmonary dysfunction observed in ARDS. Administration of exogenous surfactant could have protective effects during hyperoxia. Methods Male BALB/c mice (8–10 weeks), a strain highly sensitive to hyperoxia, received the exogenous surfactant-containing protein SP-B and SP-C by intranasal instillation 12 h before starting 24 h of exposure to hyperoxia in an inhalation chamber and were compared to mice receiving hyperoxia alone and to controls subjected to normoxia. Results Compared to the hyperoxia group, the administration of exogenous surfactant was able to reduce lung inflammation through a reduction in the influx of neutrophils and inflammatory biomarkers such as TNF, IL-17, and HMGB1 expression. The antioxidant activity prevented oxidative damage by reducing lipid peroxidation and protein carbonylation and increasing superoxide dismutase activity when compared to the hyperoxia group. Conclusion Our results offer new perspectives on the effects and the mechanism of exogenous surfactant in protecting the airway and lungs, in oxygen-rich lung microenvironment, against oxidative damage and aggravation of acute inflammation induced by hyperoxia.

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“…TNF‐α, a master regulator of inflammation with a critical role in the initiation, maintenance, and/or progression of inflammation, was unchanged in both genders following 6 weeks of CS exposure. These findings correlate and contradict with multiple basic and clinical studies with respect to the organ studied, duration of CS exposure, the amount of cigarette smoked per day, and the presence or absence of comorbidities (Feng et al, ; Machado et al, ; Mizia‐Stec, Zahorska‐Markiewicz, & Gasior, ; Parameswaran & Patial, ; Petrescu, Voican, & Silosi, ; Szulinska et al, ; Verschuere et al, ). Inflammation is generally associated with an anti‐inflammatory (i.e., IL‐10, IL‐13) and profibrotic (i.e., TGF‐β) response depending on the severity and the duration of inflammation.…”

Section: Discussionmentioning

confidence: 71%

Gender‐biased kidney damage in mice following exposure to tobacco cigarette smoke: More protection in premenopausal females

et al. 2020

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Multiple clinical studies documented renal damage in chronic cigarette smokers (CS) irrespective of their age and gender. Premenopausal female smokers are known to exert a certain cardiovascular and renal protection with undefined mechanisms.Given the multiple demographic variables within clinical studies, this experimental study was designed to be the first to assess whether gender-biased CS-induced kidney damage truly exists between premenopausal female and age-matched C57Bl6J male mice when compared to their relative control groups. Following 6 weeks of CS exposure, cardiac function, inflammatory marker production, fibrosis formation, total and glomerular ROS levels, and glomerulotubular homeostasis were assessed 2 | MATERIALS AND METHODS | AnimalsAll animal experiments were carried out according to an experimental protocol approved by the Institutional Animal K E Y W O R D S cigarette smoking, gender differences, inflammation, kidney damage, oxidative stress | 3 of 17 KAPLAN et AL.

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The administration of surfactant decreased oxidative stress in lungs of mice exposed to cigarette smoke

Cited by 8 publications

References 52 publications

Exogenous surfactant reduces inflammation and redox imbalance in rats under prone or supine mechanical ventilation

Exogenous surfactant reduces inflammation and redox imbalance in rats under prone or supine mechanical ventilation

Exogenous surfactant prevents hyperoxia-induced lung injury in adult mice

Gender‐biased kidney damage in mice following exposure to tobacco cigarette smoke: More protection in premenopausal females

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