The adolescent with a chronic condition. Part I: developmental issues

Jc, Suris; Michaud, Pierre; Viner, Russell

doi:10.1136/adc.2003.045369

Cited by 404 publications

(387 citation statements)

References 63 publications

Supporting

Mentioning

338

Contrasting

Unclassified

Order By: Relevance

“…It ahs been shown that self-image is affected negatively by chronic illness in children and adolescents. 41,42,57 In the current study, young childhood cancer survivors reportedly had lower self-esteem than the general population controls. However, high self-esteem in controls was related positively only to social outcomes, and not to educational outcomes (data not shown).…”

Section: Discussionmentioning

confidence: 46%

“…Two personal characteristics, physical health problems and self-esteem, and one familial factor, parental education, were related positively to survivors' educational and social outcomes, with low selfesteem and low parental education level showing the strongest relation to poor survivor outcomes. Experiencing physical problems may reflect the chronicity of late effects, 41 which can interfere with school attendance and learning. Alternatively, physical health problems may mediate the relation between survivors' self-esteem and social and educational outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…Self-esteem is a personal characteristic that may influence these outcomes, because self-esteem is affected negatively in children and adolescents with chronic illnesses. 41,42 Using data from a Canadian national, populationbased study, in this analysis, first, we compared parent-reported educational and social outcomes among child and adolescent survivors of childhood cancer with a population-based control group of individuals who had no cancer history. Second, among survivors only, we examined the effect of specific clinical (type of cancer and treatment), personal (physical health problems, stressful events, self-esteem), and sociodemographic characteristics (child's age, gender, parental education) on educational and social outcomes.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Educational and social late effects of childhood cancer and related clinical, personal, and familial characteristics

Barrera

Shaw

Speechley

et al. 2005

Cancer

289

265

View full text Add to dashboard Cite

The protein human CC chemokine ligand 2 (CCL2, also known as monocyte chemoattractant protein 1 or MCP‐1) has been synthesized using a combination of solid phase peptide synthesis (SPPS) and native chemical ligation (NCL). The thioester‐peptide segment was synthesized using the sulfonamide safety‐catch linker and 9‐fluorenylmethoxycarbonyl (Fmoc) SPPS, and pseudoproline dipeptides were used to facilitate the synthesis of both CCL2 fragments. After assembly of the full‐length peptide chain by NCL, a glutathione redox buffer was used to fold and oxidize the CCL2 protein. Synthetic human CCL2 binds to and activates the CCR2 receptor on THP‐1 cells, as expected. CCL2 was crystallized and the structure was determined by X‐ray diffraction at 1.9‐Å resolution. The structure of the synthetic protein is very similar to that of a previously reported structure of recombinant human CCL2, although the crystal form is different. The functional CCL2 dimer for the crystal structure reported here is formed around a crystallographic twofold axis. The dimer interface involves residues Val9‐Thr10‐Cys11, which form an intersubunit antiparallel β‐sheet. Comparison of the CCL2 dimers in different crystal forms indicates a significant flexibility of the quaternary structure. To our knowledge, this is one of the first crystal structures of a protein prepared using the sulfonamide safety‐catch linker and NCL. © 2010 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 94: 350–359, 2010. This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com

show abstract

Section: Discussionmentioning

confidence: 46%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Educational and social late effects of childhood cancer and related clinical, personal, and familial characteristics

Barrera

Shaw

Speechley

et al. 2005

Cancer

289

265

View full text Add to dashboard Cite

show abstract

“…A cancer diagnosis and its treatment lead to increased dependency on parents and/or partners and sets AYA patients apart from their healthy peers. AYA autonomy and the development of identity in general depends largely on peer acceptance and relationships 26. Not unexpectedly, studies have shown that support from other AYA patients with cancer is incredibly important for this age group in helping them to cope with their disease 27.…”

Section: Discussionmentioning

confidence: 99%

Empowerment in adolescents and young adults with cancer: Relationship with health‐related quality of life

Kaal

Husson

Duivenboden³

et al. 2017

Cancer

View full text Add to dashboard Cite

BACKGROUNDThe difficulties adolescents and young adults (AYAs) encounter during a cancer experience may result in a reduction in or absence of empowerment. The aims of the current study were to assess levels of empowerment and associated (demographic, clinical, or psychological) factors and examine the association between empowerment and health‐related quality of life (HRQOL) among AYA patients with cancer.METHODSPatients aged 18 to 35 years at time of cancer diagnosis and who were seen by 1 of the members of the specialized multidisciplinary AYA team of the Radboud University Medical Center were invited to complete questionnaires regarding empowerment; HRQOL; and sociodemographic, clinical, and psychological characteristics (autonomy, coping, unmet social support needs, and psychological distress).RESULTSA total of 83 AYA patients completed the questionnaires. The mean age of the participants at the time of diagnosis was 27.5 years. The vast majority had been treated with chemotherapy (86%), had a more advanced stage of disease, and had completed treatment at the time of participation (74%). The mean empowerment level was 154.1 (standard deviation, 17.8) with a range of 114 to 200. Multivariate analysis demonstrated that the autonomy subscales of self‐awareness (β = .35), capacity for managing new situations (β = .19), and social support (β = .35) were found to be positively associated with empowerment. Coping difficulties (β = ‐.19) were found to be negatively associated with empowerment. Empowerment was independently associated with physical (β = .31), psychological (β = .50), social (β = .39), religious (β = .33), and total HRQOL (β = .52; all P<.01).CONCLUSIONSLow levels of empowerment were associated with low levels of autonomy and social support, female sex, and coping difficulties among AYA patients with cancer. Recognizing these patients as candidates for empowerment interventions ultimately could help to improve HRQOL in late adolescence and young adulthood. Cancer 2017;123:4039‐47. © 2017 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

show abstract

“…The prevalence of non-adherence in adolescent transplant recipients can be as high as 50% [20]. One must remember, that some degree of nonadherence is part of normal adolescence behaviour [21]. Transition services therefore, have to minimize this risk taking behaviour and its consequences.…”

Section: The Importance Of Transition Servicesmentioning

confidence: 99%

The management of childhood liver diseases in adulthood

Joshi

Gupta

Samyn

et al. 2017

Journal of Hepatology

View full text Add to dashboard Cite

SummaryAn increasing number of patients with childhood liver disease survive into adulthood. These young adults are now entering adult services and require ongoing management. Aetiologies can be divided into liver diseases that develop in young adults which present to adult hepatologists i.e., biliary atresia and Alagille syndrome or liver diseases that occur in children/adolescents and adults i.e., autoimmune hepatitis or Wilson's disease. To successfully manage these young adults, a dynamic and responsive transition service is essential. In this review, we aim to describe the successful components of a transition service highlighting the importance of self-management support and a multi-disciplinary approach. We will also review some of the liver specific aetiologies which are unique to young adults, offering an update on pathogenesis, management and outcomes. Ó

show abstract

The adolescent with a chronic condition. Part I: developmental issues

Cited by 404 publications

References 63 publications

Educational and social late effects of childhood cancer and related clinical, personal, and familial characteristics

Educational and social late effects of childhood cancer and related clinical, personal, and familial characteristics

Empowerment in adolescents and young adults with cancer: Relationship with health‐related quality of life

The management of childhood liver diseases in adulthood

Contact Info

Product

Resources

About