Education is a fundamental component for developing social, economic, and cultural competencies on an individual level while promoting equality and supporting economic growth on a societal level. This study uses Palestine as a case study to explore the relationship between the academic focus on information systems in education and educational outcomes. In addition, the study examines in detail the educational studies conducted in Palestine. A dataset was constructed by filtering publications in the Web of Science (WoS) database using the keywords ‘Palestine’ and ‘education.’ Bibliometric analyses were conducted using Vosviewer, including co-author, keyword, country citation, source citation, and bibliographic coupling analyses. The study further examines the correlation between PISA mathematics scores and the number of academic studies on educational information systems through bivariate analysis. The results indicate a significant positive relationship between the focus on information systems and educational success, highlighting countries that prioritize this area as higher performers in PISA assessments. Finally, recommendations are proposed to enhance the role of information systems in education and their potential economic contributions to Palestine.