The adrenal gland microenvironment in health, disease and during regeneration

Kanczkowski, Waldemar; Sue, Mariko; Bornstein, Stefan R.

doi:10.1007/bf03401519

Cited by 24 publications

(19 citation statements)

References 142 publications

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“…t-SNE, t-distributed stochastic neighbour embedding conditions immune cells to return to systemic circulation, via lymph or blood, is an interesting notion needed future study. In fact, the immune-adrenal interactions within the adrenal microenvironment play an important role in health, disease pathophysiology and regeneration (Kanczkowski et al, 2015(Kanczkowski et al, , 2017. Many immune cells, including T cells, macrophages and neutrophils, stay in direct cell-cell contact with adrenal and endothelial cells, as observed via electron microscopic analysis.…”

Section: Discussionmentioning

confidence: 99%

Single‐cell transcriptomes reveal characteristic features of cell types within the human adrenal microenvironment

Lin

Liao

Chen

et al. 2021

Journal Cellular Physiology

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Various cells within the adrenal microenvironment are important in maintaining the body homeostasis. However, our understanding of adrenal disease pathogenesis is limited by an incomplete molecular characterization of the cell types responsible for the organ's multiple homeostatic functions. We report a cellular landscape of the human adrenal gland using single-cell RNA sequencing. We reveal characteristic features of cell types within the human adrenal microenvironment and found immune activation of nonimmune cells in the adrenal endothelial cells. We also reveal that abundant immune cells occupied a lot of space in adrenal gland. Additionally, Sex-related diversity in the adrenocortical cells and different gene expression profiles between the left and right adrenal gland are also observed at single-cell resolution. Together, at single-cell resolution, the transcriptomic map presents a comprehensive view of the human adrenal gland, which serves as a fundamental baseline description of this organ and paves a way for the further studies of adrenal diseases.

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Section: Discussionmentioning

confidence: 99%

Single‐cell transcriptomes reveal characteristic features of cell types within the human adrenal microenvironment

Lin

Liao

Chen

et al. 2021

Journal Cellular Physiology

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“…У экспериментальных животных, например у мышей ob/ob или крыс Zucker fa/fa, имеется тенденция к повышению уровня ГКС и альдостерона плазмы [69]. Согласно данным некоторых исследований, увеличение уровня гормонов коры надпочечников, обнаруженное у мышей, было ассоциировано с гиперактивностью гипоталамогипофизарно-надпочечниковой оси, гиперплазией коры надпочечников, потерей чувствительности к лептину и увеличением конверсии 11-дегидрокортикостерона в кортикостерон в периферических тканях.…”

Section: механизмы активации ггнс при ожиренииunclassified

Fat tissue and adrenal function: mechanisms of mutual influence

et al. 2019

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Мазурина Наталья Валентиновна-к.м.н., ведущий научный сотрудник отдела терапевтической эндокринологии Федерального государственного бюджетного учреждения «Национальный медицинский исследовательский центр эндокринологии Министерства здравоохранения Российской Федерации»;

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“…Epinephrine and norepinephrine, the major catecholamines for the maintainance of the blood pressure, are produced in the medulla of the adrenal gland (glandulasuprarenalis). Aldosteron and glucocorticoids are produced in the cortex (zona glomerulosa and zona fasciculata, respectively) [75].…”

Section: Focus 1:necroinflammation In the Adrenal Glandmentioning

confidence: 99%

The clinical relevance of necroinflammation—highlighting the importance of acute kidney injury and the adrenal glands

et al. 2018

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Necroinflammation is defined as the inflammatory response to necrotic cell death. Different necrotic cell death pathways exhibit different immune reponses, despite a comparable level of intracellular content release (referred to as damage associated molecular patterns or DAMPs). In addition to DAMP release, which is inevitably associated with necrotic cell death, the active production of pro/anti-inflammatory cytokines characterizes certain necrotic pathways. Necroptosis, ferroptosis and pyroptosis, therefore, are immunogenic to a different extent. In this review, we discuss the clinical relevance of necroinflammation highlighting potential human serum markers. We focus on the role of the adrenal glands and the lungs as central organs affected by systemic and/or local DAMP release and underline their role in intensive care medicine. In addition, data from models of acute kidney injury (AKI) and kidney transplantation have significantly shaped the field of necroinflammation and may be helpful for the understanding of the potential role of dialysis and plasma exchange to treat ongoing necroinflammation upon intensive care unit (ICU) conditions. In conclusion, we are only beginning to understand the importance of necroinflammation in diseases and transplantation, including xenotransplantation. However, given the existing efforts to develop inhibitors of necrotic cell death (ferrostatins, necrostatins, etc), we consider it likely that interference with necroinflammation reaches clinical routine in the near future.

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The adrenal gland microenvironment in health, disease and during regeneration

Cited by 24 publications

References 142 publications

Single‐cell transcriptomes reveal characteristic features of cell types within the human adrenal microenvironment

Single‐cell transcriptomes reveal characteristic features of cell types within the human adrenal microenvironment

Fat tissue and adrenal function: mechanisms of mutual influence

The clinical relevance of necroinflammation—highlighting the importance of acute kidney injury and the adrenal glands

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