The Adrenal

Lin, Lin; Achermann, John C.

doi:10.1159/000080495

Cited by 10 publications

(6 citation statements)

References 121 publications

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“…Clinically these patients do not generally require mineralocorticoid replacement, hence identification may affect treatment choices. 3 …”

Section: Other Rare Causes Of Adrenal Insufficiencymentioning

confidence: 99%

“…Clinically these patients do not generally require mineralocorticoid replacement, hence identification may affect treatment choices. 3 Drug-induced adrenal insufficiency Ketoconazole, metyrapone, mifepristone, aminoglutethimide and etomidate inhibit corticosteroid metabolism and potentially lead to adrenal insufficiency during treatment of Cushing's syndrome. 38 Iatrogenic adrenal insufficiency may occur during treatment with megestrol, a synthetic progestational agent that is used as an appetite stimulant.…”

Section: Other Rare Causes Of Adrenal Insufficiencymentioning

confidence: 99%

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The diagnosis and investigation of adrenal insufficiency in adults

2009

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There is considerable variation in the methods used to diagnose and investigate adrenal insufficiency in clinical practice. These include a range of adrenocorticotropin (ACTH) stimulation and other dynamic testing protocols, serum cortisol cut-off values for diagnosis and tests used for differential diagnosis. With the introduction of modern cortisol and ACTH assays, the interpretation of tests used for diagnosis and differential diagnosis has become more complex and requires local validation. This review examines the basis of normal hypothalamic-pituitary -adrenal axis function and adrenal insufficiency states based upon an evidence base accumulated over the past four decades. The role of the laboratory in the differential diagnosis and interpretation based upon assay methodology is discussed. The accurate identification of patients who may benefit from corticosteroid replacement in special settings such as critical illness is challenging and will be explored.

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“…Clinically these patients do not generally require mineralocorticoid replacement, hence identification may affect treatment choices. 3 …”

Section: Other Rare Causes Of Adrenal Insufficiencymentioning

confidence: 99%

Section: Other Rare Causes Of Adrenal Insufficiencymentioning

confidence: 99%

The diagnosis and investigation of adrenal insufficiency in adults

2009

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“…Signs and symptoms may not be specific and are due to glycocorticoid or/and mineralcorticoid deficiency. In patients with chronic adrenal insufficiency, the onset is usually insidious, with vague complaints of chronic fatigue, anorexia, nausea, vomiting, salt craving, skin hyperpigmentation and weight loss [1][2][3][4][5][6]. Hyponatraemia and hyperkalaemia along with a moderate elevation in urea, creatinine and haematocrit are the classical laboratory findings.…”

Section: Commentarymentioning

confidence: 99%

A girl with progressive fatigue and hyponatremia: answer

et al. 2010

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“…Corticotropin-releasing factor (CRF) participates in the control of depression (Holmes et al, 2003;Holsboer, 2003). Pituitary ACTH regulates glucocorticoid metabolism (Coulter et al, 2002;Lin and Achermann, 2004;Jacobson, 2005).…”

Section: Neuropeptide Functions In Brain and Endocrine Systemsmentioning

confidence: 99%

Protease Pathways in Peptide Neurotransmission and Neurodegenerative Diseases

Hook

2006

Cell Mol Neurobiol

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1. Recent research demonstrates the critical importance of neuroproteases for the production of peptide neurotransmitters, and for the production of toxic peptides in major neurodegenerative diseases that include Alzheimer's (AD) and Huntington's diseases. This review describes the strategies utilized to identify the appropriate proteases responsible for producing active peptides for neurotransmission, with application of such approaches for defining protease mechanisms in neurodegenerative diseases. 2. Integration of multidisciplinary approaches in neurobiology, biochemistry, chemistry, proteomics, molecular biology, and genetics has been utilized for neuroprotease studies. These investigations have identified secretory vesicle cathepsin L for the production of the enkephalin opioid peptide neurotransmitter and other neuropeptides. Furthermore, new results using these strategies have identified secretory vesicle cathepsin B for the production of beta-amyloid (Abeta) in the major regulated secretory pathway that provides activity-dependent secretion of Abeta peptides, which accumulate in AD. 3. CNS neuroproteases that participate in peptide neurotransmission and in neurodegenerative diseases represent new candidate drug targets that may be explored in future research for the development of novel therapeutic agents for neurological conditions.

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The Adrenal

Cited by 10 publications

References 121 publications

The diagnosis and investigation of adrenal insufficiency in adults

The diagnosis and investigation of adrenal insufficiency in adults

A girl with progressive fatigue and hyponatremia: answer

Protease Pathways in Peptide Neurotransmission and Neurodegenerative Diseases

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