The adrenergic receptors: structure/function and regulation

Lefkowitz, R. J.

doi:10.1016/0014-2999(90)91303-s

Cited by 1 publication

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“…NE has differential effects on target neurons depending on the adrenergic receptor subtype(s) present. Adrenergic receptors are G-protein-coupled receptor (GPCRs) that can be broadly classified as α1, α2, or β receptors, each of which has three subtypes (α1A-C, α2A-C, and β1-3) (for review, see (Lefkowitz, 1990;Strosberg, 1993)). Herbert & Flügge, 1995;Scheinin et al, 1994;Unnerstall, Fernandez, & Orensanz, 1985).…”

Section: Norepinephrine Receptor Expression In the Kfmentioning

confidence: 99%

Neurochemistry of the Kölliker‐Fuse nucleus from a respiratory perspective

Varga

Maletz

Bateman

et al. 2020

Journal of Neurochemistry

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The Kölliker‐Fuse nucleus (KF) is a functionally distinct component of the parabrachial complex, located in the dorsolateral pons of mammals. The KF has a major role in respiration and upper airway control. A comprehensive understanding of the KF and its contributions to respiratory function and dysfunction requires an appreciation for its neurochemical characteristics. The goal of this review is to summarize the diverse neurochemical composition of the KF, focusing on the neurotransmitters, neuromodulators, and neuropeptides present. We also include a description of the receptors expressed on KF neurons and transporters involved in each system, as well as their putative roles in respiratory physiology. Finally, we provide a short section reviewing the literature regarding neurochemical changes in the KF in the context of respiratory dysfunction observed in SIDS and Rett syndrome. By over‐viewing the current literature on the neurochemical composition of the KF, this review will serve to aid a wide range of topics in the future research into the neural control of respiration in health and disease.

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