The Adult Rat Hippocampus Contains Primordial Neural Stem Cells

Palmer, Theo D.; Takahashi, Jun; Gage, Fred H.

doi:10.1006/mcne.1996.0595

Cited by 996 publications

(728 citation statements)

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“…There is one report that activation of the cAMP pathway in cultured progenitor cells increases neuronal differentiation (Palmer et al 1997). The potential role of the cAMP-CREB cascade in neurogenesis is of particular interest because of our previous studies demonstrating that antidepressant treatment up-regulates this pathway (Figure 2) (see Duman et al 1997Duman et al , 2000.…”

Section: Role Of the Camp-creb Cascade In Adult Neurogenesismentioning

confidence: 99%

“…There are also reports that neurotrophic factors, including BDNF, influence neurogenesis. Incubation of cultured progenitor cells with BDNF is reported to increase the differentiation of cells into neurons (Palmer et al 1997). There is also an in vivo study where BDNF administered intraventricularly was found to increase neurogenesis in the subventricular zone, the region that gives rise to new neurons in the olfactory bulb (Zigova et al 1998).…”

Section: Regulation Of Adult Neurogenesis By Neurotrophic Factorsmentioning

confidence: 99%

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Regulation of Adult Neurogenesis by Antidepressant Treatment

Duman

Nakagawa

Malberg

2001

Neuropsychopharmacology

428

249

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Demonstration of neurogenesis in adult brainOur understanding of how the brain functions and undergoes adaptation and plasticity has changed dramatically over the past several years. A great deal of work has demonstrated that altered levels of neurotransmitters, second messenger pathways, and gene expression profiles underlie cellular and behavioral plasticity. This includes models of learning and memory as well as models of depression, anxiety, and psychosis, and the long-term actions of psychotropic drugs. However, it is now becoming increasing evident that changes in cellular morphology and even more pronounced alterations in brain structure also contribute to neural plasticity or remodeling. At the cellular level these changes can occur in the form of up or down-regulation of synapse formation and spine density or extension and retraction of dendrites. Another very dramatic example is up or down-regulation of neurogenesis in adult brain. Studies in recent years demonstrate that new cell birth occurs in adult brain and that the rate of neurogenesis and the survival of new neurons is regulated by a number of environmental, endocrine, and pharmacological treatments.In this paper we discuss the evidence that structural remodeling may be involved in the pathophysiology and treatment of mood disorders. The potential role of neurogenesis is also discussed as well as the molecular mechanisms which underlie antidepressant regulation of new cell birth and survival. The studies to date suggest an exciting possibility for the role of neurogenesis

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Section: Role Of the Camp-creb Cascade In Adult Neurogenesismentioning

confidence: 99%

Section: Regulation Of Adult Neurogenesis By Neurotrophic Factorsmentioning

confidence: 99%

Regulation of Adult Neurogenesis by Antidepressant Treatment

Duman

Nakagawa

Malberg

2001

Neuropsychopharmacology

428

249

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“…They play a major role in the development of the embryonic central nervous system and continue to function throughout adulthood [1][2][3]. The proliferation and differentiation of NSCs depend on microenvironmental niche signals [4,5], including a number of growth factors such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) [6].…”

Section: Introductionmentioning

confidence: 99%

Upregulation of Flk-1 by bFGF via the ERK pathway is essential for VEGF-mediated promotion of neural stem cell proliferation

et al. 2007

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“…Specialized stem cell niches comprised of differentiated cells, blood vessels and extracellular matrix support adult stem cells and provide survival, differentiation and/or self-renewal cues (Wagers et al, 2002;Morrison and Spradling, 2008;Voog and Jones, 2010). Adult stem cell niches have now been identified in most adult tissues in mammals, including the highly regenerative blood Weissman, 1994, Morrison et al, 1995), intestine (Barker et al, 2007), skin (Blanpain et al, 2007) and mammary gland (Visvader, 2009), as well as the less regenerative skeletal and cardiac muscle (Beltrami et al, 2003;Morgan and Partridge, 2003;Rando, 2005) and brain (Lois and Alvarez-Buylla, 1993;Morshead et al, 1994;Palmer et al, 1997;Gage et al, 1998;Doetsch et al, 1999).…”

mentioning

confidence: 99%