The Adult-Specific Ubiquinone Q8 Functions as an Antioxidant in the Filarial Parasite, Setaria digitata

Mohan, Subburaman; Pradeep, Chellappan G.; Kumar, Rakesh; Jayakumar, K.; Raj, Rishi

doi:10.1006/bbrc.2001.5882

Cited by 5 publications

(3 citation statements)

References 29 publications

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“…Furthermore, two ubiquinones (Q 6 and Q 8 ) have been identified in the ESPs of the filarial parasite S. digitate ( Mohan et al., 2001 ). The preferential release of ubiquinone Q 8 in the ESPs has an antioxidant role by inhibiting lipid peroxidation while the ubiquinone Q 6 is primarily involved in the electron transport chain ( Mohan et al., 2001 ).…”

Section: Resultsmentioning

confidence: 99%

“…SODs are detected in the ESPs from all life stages, although the relative abundance of the enzyme in each life stage is not clear (Hewitson et al, 2008;Moreno and Geary, 2008;Bennuru et al, 2009). Furthermore, two ubiquinones (Q 6 and Q 8 ) have been identified in the ESPs of the filarial parasite S. digitate (Mohan et al, 2001). The preferential release of ubiquinone Q 8 in the ESPs has an antioxidant role by inhibiting lipid peroxidation while the ubiquinone Q 6 is primarily involved in the electron transport chain (Mohan et al, 2001).…”

Section: Superoxide Dismutase Dismantle Superoxide and Hydrogen Peroxide Released By Host Immune Cellsmentioning

confidence: 99%

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The Secretome of Filarial Nematodes and Its Role in Host-Parasite Interactions and Pathogenicity in Onchocerciasis-Associated Epilepsy

Hotterbeekx

Perneel

Vieri

et al. 2021

Front. Cell. Infect. Microbiol.

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Filarial nematodes secrete bioactive molecules which are of interest as potential mediators for manipulating host biology, as they are readily available at the host-parasite interface. The adult parasites can survive for years in the mammalian host, due to their successful modulation of the host immune system and most of these immunomodulatory strategies are based on soluble mediators excreted by the parasite. The secretome of filarial nematodes is a key player in both infection and pathology, making them an interesting target for further investigation. This review summarises the current knowledge regarding the components of the excretory-secretory products (ESPs) of filarial parasites and their bioactive functions in the human host. In addition, the pathogenic potential of the identified components, which are mostly proteins, in the pathophysiology of onchocerciasis-associated epilepsy is discussed.

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Section: Resultsmentioning

confidence: 99%

Section: Superoxide Dismutase Dismantle Superoxide and Hydrogen Peroxide Released By Host Immune Cellsmentioning

confidence: 99%

The Secretome of Filarial Nematodes and Its Role in Host-Parasite Interactions and Pathogenicity in Onchocerciasis-Associated Epilepsy

Hotterbeekx

Perneel

Vieri

et al. 2021

Front. Cell. Infect. Microbiol.

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“…While both Q6 and Q8 are formed and present in the adult stage, the microfilariae (mf), as well as the electron transfer complexes from adult mitochondria, have been recently shown to contain only Q6. The second ubiquinone Q8 is present only in the adult and absent in the mf (Mohan et al , 2001). Setaria digitata is unique in having peculiarities such as hydrogen peroxide (H 2 O 2 ) production, cyanide insensitivity and absence of cytochromes and presence of quinones (Santhamma & Raj, 1991a).…”

Section: Oxidative and Respiratory Metabolismmentioning

confidence: 99%

Biochemical composition and metabolic pathways of filarial worms Setaria cervi: search for new antifilarial agents

Ahmad

Srivastava

2007

J. Helminthol.

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The main problem regarding the chemotherapy of filariasis is that no safe and effective drug is available yet to combat the adult human filarial worms. Setaria cervi, the causal organism of setariasis and lumbar paralysis in cattle, is routinely employed as a model organism for conducting biochemical and enzymatic studies on filarial parasites. In view of the practical difficulties in procuring human strains of Wuchereria bancrofti and Brugia malayi for drug screening, the bovine filarial parasite S. cervi, resembling the human species in having microfilarial periodicity and chemotherapeutic response to known antifilarial agents, is widely used as a model in such studies. For a rational approach to antifilarial chemotherapy, knowledge of the biochemical composition and metabolic pathways of this helminth parasite may be of paramount importance, so that more potent antifilarial agents based on specific drug targets can be identified in drug discovery programmes. The present review provides an update on the biochemistry of the important metabolic pathways functioning within this potentially important bovine parasite, that have so far been studied, and on those that need to be investigated further so as to identify novel drug targets that can be exploited for designing new antifilarial drugs.

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Effect of Diethylcarbamazine Citrate and Setaria equina Excretory–Secretory Material on Rat Hepatocellular Carcinoma

Abdel‐Latif

Sakran

El-Shahawi

et al. 2014

Arch. Immunol. Ther. Exp.

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Diethylcarbamazine citrate (DEC) has been known for its efficacy to eradicate bancroftian filariasis in Egypt and other countries in the world. One of the known effects was to decrease the level of circulating filarial antigen in the patient's serum. The target of this study was to examine the effect of DEC, excretory-secretory (ES) material from the filarial parasite Setaria equina or a combination of both on the status of oxidative stress and pathogenesis of rat hepatocellular carcinoma (HCC) induced by diethylnitrosamine and 2-acetylaminofluorene. This could be tested in vitro using nitroblue tetrazolium reduction test for measuring the level of superoxide anion (O₂(•-)) released from rat peritoneal macrophages. For in vivo test, a single dose before induction of carcinogenesis or continually repeated doses with DEC, ES or DEC + ES was used. Exposure of macrophages to ES could lead to a significant decrease (p < 0.01) in O₂(•-) release, while DEC (200 μM) could modulate such effect with significant increase (p < 0.05). Pathogenesis of liver cancer and treatment were evaluated using histological investigation, level of antioxidant and liver function enzymes. Repeated ES doses could increase the activity of antioxidant enzymes, especially the catalase enzyme and show a protective effect on liver architecture. DEC could modulate the later effects when combined with ES. No significant effect on the liver function enzymes after treatment was observed. Nuclear factor κB was found to be localized only in the cytoplasm after single and repeated treatments with ES. This study could indicate the effect of S. equina ES as antioxidant against rat HCC, while DEC could modulate such effect when combined with it.

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The Adult-Specific Ubiquinone Q8 Functions as an Antioxidant in the Filarial Parasite, Setaria digitata

Cited by 5 publications

References 29 publications

The Secretome of Filarial Nematodes and Its Role in Host-Parasite Interactions and Pathogenicity in Onchocerciasis-Associated Epilepsy

The Secretome of Filarial Nematodes and Its Role in Host-Parasite Interactions and Pathogenicity in Onchocerciasis-Associated Epilepsy

Biochemical composition and metabolic pathways of filarial worms Setaria cervi: search for new antifilarial agents

Effect of Diethylcarbamazine Citrate and Setaria equina Excretory–Secretory Material on Rat Hepatocellular Carcinoma

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