“…Normal aging human brain was shown to accumulate AGEs within neurons and glial cells [10,11] as well as in senile plaques [12]. Beside this "physiological" occurrence of AGEs, pathological accumulations of glycated proteins were found in neurodegenerative diseases such as Alzheimer's (AD) [13], Parkinson's [14], amyotrophic lateral sclerosis (ALS) [15,16], vascular dementia (VD) [17], CreutzfeldJakob (CJD) [18], Pick', and Lewy body diseases [7].…”