The Advancement Of Tumor Microenvironment In Pancreatic Carcinoma

Abstract

Pancreatic cancer is the known kind of tumor biologically featured as high malignancy, lack of effective methods for diagnosis and treatment. Tumor microenvironment is generally considered as an important promotor in tumor invasion and metastasis. This review aims to deeply understand the mechanism of the tumor progression and validly provide the evidence for diagnosis and treatment by means of focusing on the advances in the research of pancreatic cancer in the fields of stromal cells, inflammation and hypoxia in the tumor microenvironment of pancreatic carcinoma.

Mechanisms of the Antitumor Activity of Low Molecular Weight Heparins in Pancreatic Adenocarcinomas

“…The presence of desmoplasia is a hallmark in PDAC pathogenesis and progression and can be recognized mainly at the primary tumor site [19,20]. The term tumor microenvironment (TME) is used to describe an assembly of elements that form pancreatic neoplasia and consists of tumor cells, various nonmalignant stromal cells, and active factors as shown in Figure 1 [21]. The tumor microenvironment is a dynamic entity, and this may account for the diversity observed in different tissues; however, main features such as desmoplasia, abnormal vascularity, and fibroblast activation are almost always present [22][23][24].…”