2019
DOI: 10.3389/fimmu.2019.00858
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The Advances in Molecular and New Point-of-Care (POC) Diagnosis of Schistosomiasis Pre- and Post-praziquantel Use: In the Pursuit of More Reliable Approaches for Low Endemic and Non-endemic Areas

Abstract: Like soil-transmitted helminth infections, schistosomiasis is an important neglected tropical disease (NTD) related to poverty with a major impact on public health in developing countries. Diagnosis of active infection is crucial for surveillance of controlled or post-elimination schistosomiasis areas. In addition, the use of conventional diagnostic tools in non-exposed populations (such as travelers) results in misdiagnoses in the prepatent period of infection. Also, the accuracy of standard tests applied in … Show more

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Cited by 207 publications
(29 citation statements)
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“…Aberrant results have also been reported related to the use of the POC-CCA assay in Brazil. 36,37 Some of these results may be attributable to the fact that Brazil requires the assay to be assembled in Brazil using components from the South African supplier, which could result in different levels of quality control of the final product, 37 or this could be related to the issue of different batches of components mentioned earlier.…”
Section: Additional Considerations In Using Poc-cca For Mappingmentioning
confidence: 99%
“…Aberrant results have also been reported related to the use of the POC-CCA assay in Brazil. 36,37 Some of these results may be attributable to the fact that Brazil requires the assay to be assembled in Brazil using components from the South African supplier, which could result in different levels of quality control of the final product, 37 or this could be related to the issue of different batches of components mentioned earlier.…”
Section: Additional Considerations In Using Poc-cca For Mappingmentioning
confidence: 99%
“…The development of molecular methods to improve the diagnosis of parasitic diseases has been encouraging active research in recent years [13,14]. The detection of Schistosoma DNA by PCR in stools and urine appears to be a promising, highly sensitive, and specific tool that could improve and facilitate the diagnosis of schistosomiasis, particularly in non-endemic countries where the parasite burden can be lower [1518].…”
Section: Introductionmentioning
confidence: 99%
“…Heavy infections are usually associated with increased clinical severity due to host allergic responses, although high morbidity can also be seen in light/mild infections. Therefore, laboratory-based diagnosis is fundamental for accurate identification of AS cases (2,4,(10)(11)(12)(13)(14).…”
Section: Introductionmentioning
confidence: 99%
“…During early infection (prepatent phase: 3-7 weeks post exposure), immature forms migrate from the sites of skin penetration to several host systemic compartments, such as the lung, liver, gut, and visceral peritoneum until harboring mature bi-gender forms in the mesenteric veins ( 15 ). In this early phase, eggs are not detectable until ≅40 days post-exposure and alternative diagnostic approaches are usually applied other than parasitological tests ( 14 , 16 ). Routinely, indirect diagnostic assays such as serology and other laboratory markers like eosinophil counts are mostly used ( 1 , 2 , 4 , 17 , 18 ).…”
Section: Introductionmentioning
confidence: 99%
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