The advantages of peritoneal dialysis over hemodialysis during the COVID‐19 pandemic

Chen, Tz Heng; Wen, Yu Hua; Chen, Chun-Fan; Tan, Ann Charis; Chen, Yung Tai; Chen, Fan Yu; Lin, Chih Ching

doi:10.1111/sdi.12903

Cited by 26 publications

(28 citation statements)

References 13 publications

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“…Peritoneal dialysis (PD), a type of home dialysis therapy for end-stage renal disease, has been widely used across the world because of its convenience and flexibility [ 1 ], especially in the current COVID-19 pandemic [ 2 ]. However, long-term PD treatment will result in peritoneal fibrosis, a frequent complication due to exposure to glucose peritoneal dialysate [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Blocking core fucosylation of epidermal growth factor (EGF) receptor prevents peritoneal fibrosis progression

Yang

Wang

et al. 2021

Renal Failure

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Objective Peritoneal fibrosis (PF) ultimately causes ultrafiltration failure and peritoneal dialysis (PD) termination, but there are few effective therapies for it. Core fucosylation, which is catalyzed by α1,6-fucosyltransferase (Fut8) in mammals, may play a crucial role in PF development. This study aims to assess the effects of inhibiting core fucosylation of epidermal growth factor (EGF) receptor on PF rats. Methods PF rats (established by 4.25% glucose dialysate) were treated with either an adenovirus-Fut8 short hairpin RNA (Fut8shRNA) or adenovirus-control. Masson’s staining and net ultrafiltration were performed at week six. Fut8 level and core fucosylation of EGF receptor and collagen I in the peritoneal membrane were assessed, and EGF signaling was detected, including signal transducer and activator of transcription 3 (STAT3), nuclear factor kappa B (NF-κB) and their phosphorylation. Monocyte chemoattractant protein-1 (MCP-1) in peritoneal effluent was examined. Results Fut8 was upregulated in PF rats but decreased after Fut8shRNA treatment. EGF and EGF receptor expression was upregulated in PF rats, while core fucosylation of EGF receptor decreased after Fut8shRNA treatment. Masson’s staining results showed an increase in peritoneal thickness in PF rats but a decrease after Fut8shRNA treatment. Fut8shRNA treatment increased net ultrafiltration, reduced the expression of collagen I and MCP-1 compared to PF rats. Fut8shRNA treatment suppressed phosphorylation of STAT3 and NF-κB in the peritoneal membrane of PF rats. Conclusions Fut8shRNA treatment ameliorated the fibrotic changes in PF rats. A potential mechanism may be that Fut8shRNA treatment inactivated EGF signaling pathway by suppressing the phosphorylation of STAT3 and NF-κB.

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Section: Introductionmentioning

confidence: 99%

Blocking core fucosylation of epidermal growth factor (EGF) receptor prevents peritoneal fibrosis progression

Yang

Wang

et al. 2021

Renal Failure

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“…Home HD is also a dialysis modality that can prevent infection clusters and preserve the healthcare workforce. However, the prevalence of home HD is still relatively low [84].…”

Section: Acute Kidney Injurymentioning

confidence: 99%

Kidneys in SARS‐CoV‐2 era: A challenge of multiple faces

et al. 2022

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Introduction: With the evolution of SARS-CoV-2 pandemic, it was believed to be a direct respiratory virus. But, its deleterious effects were observed on different body systems, including kidneys. Aim of Work: In this review, we tried as much as we can to summarize what has been discussed in the literature about the relation between SARS-CoV-2 infection and kidneys since December, 2019.Methods: Each part of the review was assigned to one or two authors to search for relevant articles in three databases (Pubmed, Scopus, and Google scholar) and collected data were summarized and revised by two independent researchers. Conclusion:The complexity of COVID-19 pandemic and kidney could be attributed to the direct effect of SARS-CoV-2 infection on the kidneys, different clinical presentation, difficulties confronting dialysis patients, restrictions of the organ transplant programs, poor outcomes and bad prognosis in patients with known history of kidney diseases who got infected with SARS-CoV-2.

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“…1 In the face of the pandemic, PD has several definite advantages. 2 The risk of COVID-19 exposure is less than HD since it is performed at home, which alleviates the risk of transmission both during travel time and time spent within the health facility. Treatment is uninterrupted as physicians continue to conduct telemedicine consultations and prescriptions.…”

Section: Peritoneal Dialysis In the Days Of Covid-19mentioning

confidence: 99%

“…1 Methemoglobin cannot bind and release oxygen reversibly and results in decreased oxygen delivery leading to hypoxia. 2 Severe methemoglobinemia can have life-threatening potential and will be further deleterious when compounded by the coexistent cardiopulmonary dysfunction in COVID-19 patients. In this report, red cell exchange (REX) transfusion by apheresis is shown to be an effective treatment of dangerously rising methemoglobinemia that was refractory to other conventional treatments in a patient with severe COVID-19.…”

mentioning

confidence: 99%