2024
DOI: 10.3389/fmolb.2024.1390858
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The advent of preventive high-resolution structural histopathology by artificial-intelligence-powered cryogenic electron tomography

Jesús G. Galaz-Montoya

Abstract: Advances in cryogenic electron microscopy (cryoEM) single particle analysis have revolutionized structural biology by facilitating the in vitro determination of atomic- and near-atomic-resolution structures for fully hydrated macromolecular complexes exhibiting compositional and conformational heterogeneity across a wide range of sizes. Cryogenic electron tomography (cryoET) and subtomogram averaging are rapidly progressing toward delivering similar insights for macromolecular complexes in situ, without requir… Show more

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Cited by 2 publications
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References 244 publications
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