The adventitia and atherogenesis: removal initiates intimal proliferation in the rabbit which regresses on generation of a ‘neoadventitia’

Barker, S. G. E.; Tilling, Lorna; Miller, Gill C.; Beesley, Julian E.; Fleetwood, G.; Stavri, George T.; Baskerville, P. A.; Martin, John F.

doi:10.1016/0021-9150(94)90043-4

Cited by 129 publications

(88 citation statements)

References 27 publications

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“…Volume-rendered transmission displays, maximum intensity projection, and voxel gradient shading were displayed at various angles and threshold values of voxels. Average voxel size was [21][22][23][24][25][26][27][28] m, and images of up to 800 slices were rendered for each arterial specimen (each with a matrix of 10-20 m cubic voxels ϫ 16 bits of gray scale).…”

Section: Methodsmentioning

confidence: 99%

Enhanced coronary vasa vasorum neovascularization in experimental hypercholesterolemia.

Kwon¹,

Sangiorgi²,

Ritman³

et al. 1998

J. Clin. Invest.

283

207

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Coronary arteries contain a network of vasa vasorum in the adventitia. The three-dimensional anatomy of the vasa vasorum in early coronary atherosclerosis is unknown. This study was designed to visualize and quantitate the threedimensional spatial pattern of vasa vasorum in normal and experimental hypercholesterolemic porcine coronary arteries, using a novel computed tomography technique. Animals were killed after being fed either a high cholesterol diet ( n ϭ 4) or a control diet ( n ϭ 4) for 12 wk. The proximal left anterior descending coronary artery was removed from the heart, scanned, and reconstructed, and quantitation of vasa vasorum density was performed. Two different types of vasa vasorum were defined: first-order vasa vasorum ran longitudinally parallel to the vessel and second-order originated from first-order vasa circumferentially around the vessel wall.

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Section: Methodsmentioning

confidence: 99%

Enhanced coronary vasa vasorum neovascularization in experimental hypercholesterolemia.

Kwon¹,

Sangiorgi²,

Ritman³

et al. 1998

J. Clin. Invest.

283

207

View full text Add to dashboard Cite

show abstract

“…[18][19][20] Adventitial irritation results in focal intimal thickening, and markers applied to the adventitia can be visualized in intima. It is hypothesized that cells originating from the adventitial layer migrate and contribute to neointimal formation.…”

Section: Introductionmentioning

confidence: 99%

Needle injection catheter delivery of the gene for an antibacterial agent inhibits neointimal formation

et al. 1999

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“…The vasa vasorum have been the subject of considerable interest for more than a century (Koester, 1876), first because of their peculiar function (namely that of supplying blood to the walls of blood vessels), and second because of their possible role in atherogenesis (Nakata and Shionoya, 1966;Nakata and Kamiya, 1970;Mann, 1978;Barger et al, 1984;Crotty, 1989;Barger and Beeuwkes, 1990;Barker et al, 1993Barker et al, , 1994, coronary interventions (Cragg et al, 1983;Kwon et al, 1998a;Sanada et al, 1998), diet-induced hypercholesterolemia (Kwon et al, 1998b;Herrmann et al, 2001Herrmann et al, , 2002Wilson et al, 2002), and hypertension (Marcus et al, 1985;Kai et al, 2002;Kuwahara et al, 2002).…”

mentioning

confidence: 99%

Functional anatomy and hemodynamic characteristics of vasa vasorum in the walls of porcine coronary arteries

et al. 2003

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In this study vasa vasorum in the walls of porcine coronary arteries were examined, using three-dimensional (3D) micro-CT scanning techniques. These techniques leave the 3D structure of the vasa vasorum tree intact and thus provide a much more direct view of this structure than is possible from conventional histological sections. The study demonstrates-for the first time, we believe-both the different types and the fine architecture of these vasa vasorum. Furthermore, with the use of automated tree analysis software, it was possible to obtain quantitative geometrical data on the 3D structure of vasa vasorum trees that have not previously been available. The results indicate that despite the restrictive topology of the space in which they are present, the branching architecture of the vasa vasorum trees, which we surveyed, is surprisingly similar to that of vasculature in general. The volume of vessel wall tissue perfused or drained by a vasa vasorum tree was found to correlate well with the cross-sectional area of the root segment of the vasa vasorum tree, and the luminal surface area corresponding to this volume was found to be comparable with the surface area of an early atherosclerotic lesion. This is consistent with earlier findings that the ligation or removal of vasa vasorum leads to atherogenesis. Anat Rec Part A 272A: 526 -537, 2003. Published 2003 Key words: vasa vasorum; vessel wall perfusion; vascular branching structure; vascular diseaseThe vasa vasorum have been the subject of considerable interest for more than a century (Koester, 1876), first because of their peculiar function (namely that of supplying blood to the walls of blood vessels), and second because of their possible role in atherogenesis

show abstract

The adventitia and atherogenesis: removal initiates intimal proliferation in the rabbit which regresses on generation of a ‘neoadventitia’

Cited by 129 publications

References 27 publications

Enhanced coronary vasa vasorum neovascularization in experimental hypercholesterolemia.

Enhanced coronary vasa vasorum neovascularization in experimental hypercholesterolemia.

Needle injection catheter delivery of the gene for an antibacterial agent inhibits neointimal formation

Functional anatomy and hemodynamic characteristics of vasa vasorum in the walls of porcine coronary arteries

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