The adverse effects of cervical cancer treatment on bladder function

Farquharson, David I. M.; Shingleton, Hugh M.; Soong, Seng‐Jaw; Sanford, Shelby P.; Levy, David; Hatch, Kenneth D.

doi:10.1016/0090-8258(87)90226-5

Cited by 42 publications

(22 citation statements)

References 13 publications

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“…In consequence, the high incidence of low-compliance bladder in the RH + RT group may be caused by the presence of both the detrusor hypertonicity and the bladder fibrosis. Farquharson et al also reported a high incidence of lowcompliance bladder in the RH + RT group [7]. Since bladder, fibrosis is generally an irreversible process, poor-compliance bladder in this group remained for the long term.…”

Section: Discussionmentioning

confidence: 91%

“…There has been a considerable amount written about the urologic complications of surgical treatment and radiation therapy for cervical cancer [1][2][3][4][5][6][7]. Postoperative reduced urinary stream, urge and/or stress incontinence and urinary frequency occur in a disproportionately high number of patients [7,8].…”

Section: Introductionmentioning

confidence: 99%

“…Postoperative reduced urinary stream, urge and/or stress incontinence and urinary frequency occur in a disproportionately high number of patients [7,8]. These symptoms are believed to result from damage to the nerve supply to the bladder.…”

Section: Introductionmentioning

confidence: 99%

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The late effect of hysterectomy with or without postoperative radiotherapy on bladder dysfunction in patients with uterine cancer

1995

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A serial urodynamic study was performed in 491 patients with uterine cancer following radical hysterectomy (RH) involving postoperative pelvic radiation (RH + RT) and extended hysterectomy (EH) for 10 years after these respective treatments. The following evidence is presented: (1) increased volume of residual urine and sensory impairment occurred 1-2 months after radical hysterectomy with or without radiation, but was rarely seen in the EH group: (2) increased residual urine volume in the RH group gradually subsided 1-3 years after the treatment, while the RH + RT treatment resulted in a slight reduction: (3) late maximum cytometric capacity in the EH and RH groups remained stable throughout the study, but the RH + RT group showed a lower capacity (P <0.05) than the EH group, except in one set of determinations. (4) a high incidence of low bladder compliance in the RH group at 1-2 months decreased thereafter, whereas in the RH + RT group bladder compliance remained poor (23%) up to 7-10 years after treatment. In the EH group low bladder compliance was rarely seen: (5) sensory impairment, urinary incontinence and difficulty on urination remained unimproved in many patients in the RH + RT group, while the incidence of subsequent urological operations in the EH group was lower (P <0.05) than in the RH + RT group. Based on these findings, EH appears to be more beneficial for the retention of normal bladder function and radical hysterectomy with postoperative radiation results in deterioration of bladder activity.

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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The late effect of hysterectomy with or without postoperative radiotherapy on bladder dysfunction in patients with uterine cancer

1995

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“…Intraoperative injuries and postoperative fistulas are often used as arguments against surgery and for radiotherapy of cervical cancer (B6ttcher et al 1983;Farquharson et al 1987;Kline et al 1972;Kfitzner et at. 1986;Montana et al 1985Montana et al , 1987Perez et al 1987).…”

Section: Discussionmentioning

confidence: 99%

Urological complications after radical hysterectomy with or without radiotherapy for cervical cancer

Ralph

Tamussino

Lichtenegger

1990

Arch Gynecol Obstet

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We reviewed urologic complications in 320 patients who underwent radical abdominal hysterectomy for stage Ib-IIb cervical cancer. 145 patients received adjuvant radiotherapy, and 116 were available for urodynamic testing 1-14 years later. The overall incidence of fistulas was 4.4%. Three of eight fistulas following surgery alone healed spontaneously; all fistulas following adjuvant radiotherapy required surgical correction. Nocturia and urgency were reported more often after adjuvant radiotherapy than after surgery alone. We conclude that urologic complications after radical hysterectomy can be made more intractable by adjuvant radiotherapy.

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“…It has been reported that residual urine was an important factor leading to infection, alteration of detrusor function and deterioration in renal function [2][3][4]. Early identifica-tion of the possibility of residual urine after gynecological surgery could prevent urological complications.…”

Section: Introductionmentioning

confidence: 99%

Vesicourethral Function after Surgery for Uterine Cancer: Predictive Value of Postoperative Maximum Urethral Closure Pressure on Residual Urine

1993

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Using a urodynamic technique, vesicourethral function was evaluated in 30 patients who had undergone surgery for uterine cancer. In all 28 patients treated with radical hysterectomy, detrusor function was damaged irrespective of the use of the Cavitron ultrasonic surgical aspirator (CUSA), whereas, in 2 patients treated with semiradical hysterectomy, the function was preserved. Vesicourethral functions 3 weeks after the operation in all 28 patients treated with radical hysterectomy showed underactive detrusor function with low compliance. In 10 out of these 28 patients, postoperative maximum urethral closure pressure (MUCP) did not decrease, without relation to the use of CUSA nor to the presence of detrusor sphincter dyssynergia, and more than 5 weeks were required to reduce residual urine to less than 50 ml. On the other hand, in the remaining 18 patients, postoperative MUCP decreased, and residual urine decreased to less than 50 ml by 5 weeks after the operation. From the results obtained here, we can conclude that the evaluation of MUCP at an early phase after the operation is a useful tool to predict complications caused by residual urine, such as urinary tract infection, irreversible alteration of detrusor function or deterioration in renal function.

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The adverse effects of cervical cancer treatment on bladder function

Cited by 42 publications

References 13 publications

The late effect of hysterectomy with or without postoperative radiotherapy on bladder dysfunction in patients with uterine cancer

The late effect of hysterectomy with or without postoperative radiotherapy on bladder dysfunction in patients with uterine cancer

Urological complications after radical hysterectomy with or without radiotherapy for cervical cancer

Vesicourethral Function after Surgery for Uterine Cancer: Predictive Value of Postoperative Maximum Urethral Closure Pressure on Residual Urine

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