The Aetiological Role of Human Papillomavirus in Colorectal Carcinoma: An Iranian Population- Based Case Control Study

Ranjbar, Reza; Saberfar, Esmaeil; Shamsaie, Alireza; Ghasemian, Ehsan

doi:10.7314/apjcp.2014.15.4.1521

Cited by 27 publications

(29 citation statements)

References 20 publications

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“…Chen et al also found that the transmission of the HPV to the colorectal tissues might occur through blood circulation 10 . Since higher frequency of HPV infection in caecal and ascending colonic tissues has been determined in compare to frequency of infection in rectosigmoid tissues, this study supports the hypothesis that investigated HPV infection in colon and rectum might not occurs through direct infection 13 . HPV16 was the most frequent type in CRC in this study (24 out of 25 positive samples, 96%).…”

Section: Disclosuresupporting

confidence: 83%

Detection of Human Papilloma Virus in Colorectal Cancer by Polymerase Chain Reaction Technique in A Tertiary Care Hospital of Bangladesh

Das¹,

Hossain²,

Nasreen³

et al. 2019

Chatt Maa Shi Hosp Med Coll J

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Background: Human Papilloma Virus (HPV) infection is associated with the development of several cancers, including oral, esophageal, skin, lung, and uterine cervix. Association of HPV and colorectal cancers remains controversial. The aim of this study was to evaluate the association between HPV infection and colorectal cancer in Chattogram of Bangladesh. Materials and methods: The study was carried out in the Department of Pathology, Chattogram Medical College, Bangladesh over a period of one year from July, 2013 to June, 2014. A total of 60 cases were included in the study during the time period. Histopathological type and grading was done. HPV type 16 and 18 DNA was examined from all samples by means of Real Time PCR using type specific primer named E7 protein. Finally association between HPV types 16/18 with colorectal carcinoma was assessed by Chi-square (c2) test. Results: The mean age of 60 patients was 45.35 years (Range 17-75 years). Rectum was the common site of tumour 26 (43.3%). HPV type 16 and 18 was detected in 25 (41.7%) cases, out of whom 24 (96%) were associated with HPV16, and only one case was both HPV type 16 and 18. As regarding histological type, out of 25 cases 21 (84%) cases of adenocarcinoma, 3 (12%) case of signet ring carcinoma and only 1 (1.6%) case of mucinous carcinoma were positive for HPV. Conclusion: HPV specially subtype 16, may play a role in the oncogenesis of Colorectal Carcinoma. Chatt Maa Shi Hosp Med Coll J; Vol.18 (1); Jan 2019; Page 44-48

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Section: Disclosuresupporting

confidence: 83%

Detection of Human Papilloma Virus in Colorectal Cancer by Polymerase Chain Reaction Technique in A Tertiary Care Hospital of Bangladesh

Das¹,

Hossain²,

Nasreen³

et al. 2019

Chatt Maa Shi Hosp Med Coll J

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“…Furthermore, in the group of patients over 60 years of age, a higher proportion of HPV-positive cases had a histologic diagnosis of colorectal adenocarcinoma. According to demographic data analysis by Ranjbar et al (2014), more than 90% of individuals with both CRC and HPV infections are older than 50 years of age. Our study shows an epidemiological pattern of CRC and HPV infection in a Cuban population that is similar to what was found in other studies (Damin et al 2013, Ranjbar et al 2014).…”

Section: Discussionmentioning

confidence: 99%

“…In these studies, rates of HPV detection in tissues collected from the rectum or sigmoid colon were similar to those in tissues obtained from the cecum or ascending colon. Because HPV infection is mainly transmitted by cell surface contact, the route of viral transmission to the colon remains to be determined (Chen et al 2012, Ranjbar et al 2014). …”

Section: Discussionmentioning

confidence: 99%

Molecular evidence of high-risk human papillomavirus infection in colorectal tumours from Cuban patients

Soto

Limia

González

et al. 2016

Mem. Inst. Oswaldo Cruz

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The association between colorectal cancer and human papillomavirus (HPV) infection is still unproven. The aim of this study was to investigate the presence of high-risk HPV (HR-HPV) DNA in colorectal tissues from Cuban patients. A total of 63 colorectal formalin-fixed paraffin-embedded tissues were studied (24 adenocarcinoma, 18 adenoma, and 21 colorectal tissues classified as benign colitis). DNA from colorectal samples was analysed by quantitative real-time polymerase chain reaction to detect the most clinically relevant high HR-HPV types (HPV-16, -18, -31, -33, -45, -52, and -58). Associations between histologic findings and other risk factors were also analysed. Overall, HPV DNA was detected in 23.8% (15/63) of the samples studied. Viral infections were detected in 41.7% of adenocarcinoma (10/24) and 27.7% of adenoma cases (5/18). HPV DNA was not found in any of the negative cases. An association between histological diagnosis of adenocarcinoma and HPV infection was observed (odd ratio = 4.85, 95% confidence interval = 1.40-16.80, p = 0.009). The only genotypes identified were HPV 16 and 33. Viral loads were higher in adenocarcinoma, and these cases were associated with HPV 16. This study provides molecular evidence of HR-HPV infection in colorectal adenocarcinoma tissues from Cuban patients.

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“…It is the third leading cause of cancer dependent death in the world and there are one million new cases diagnosed per year (Ranjbar1 et al, 2014). The highest incidence rates of colorectal cancer are located in Europe, North America, and Oceania.…”

Section: Introductionmentioning

confidence: 99%

Survival of Colorectal Cancer in the Presence of Competing-Risks - Modeling by Weibull Distribution

Baghestani¹,

Daneshva²,

Pourhoseingholi³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Background: Colorectal cancer (CRC) is the commonest malignancy in the lower gastrointestinal tract in both men and women. It is the third leading cause of cancer-dependent death in the world. In Iran the incidence of colorectal cancer has increased during the last 25 years. Materials and Methods: In this article we analyzed the survival of 447 colorectal patients of Taleghani hospital in Tehran using parametric competing-risks models. The cancers of these patients were diagnosed during 1985 -2012 and followed up to 2013. The purpose was to assess the association between survival of patients with colorectal cancer in the presence of competing-risks and prognostic factors using parametric models. The analysis was carried out using R software version 3.0.2. Results: The prognostic variables included in the model were age at diagnosis, tumour site, body mass index and sex. The effect of age at diagnosis and body mass index on survival time was statistically significant. The median survival for Iranian patients with colorectal cancer is about 20 years. Conclusions: Survival function based on Weibull model compared with Kaplan-Meier survival function is smooth. Iranian data suggest a younger age distribution compared to Western reports for CRC.

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The Aetiological Role of Human Papillomavirus in Colorectal Carcinoma: An Iranian Population- Based Case Control Study

Cited by 27 publications

References 20 publications

Detection of Human Papilloma Virus in Colorectal Cancer by Polymerase Chain Reaction Technique in A Tertiary Care Hospital of Bangladesh

Detection of Human Papilloma Virus in Colorectal Cancer by Polymerase Chain Reaction Technique in A Tertiary Care Hospital of Bangladesh

Molecular evidence of high-risk human papillomavirus infection in colorectal tumours from Cuban patients

Survival of Colorectal Cancer in the Presence of Competing-Risks - Modeling by Weibull Distribution

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