The Aetiology and Management of Intersexuality

Cj, Dewhurst

doi:10.1111/j.1365-2265.1975.tb01932.x

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Pure Gonadal Dysgenesis1

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1978

1986

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Cited by 10 publications

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“…The karyotype of the embryo is 46, XY. The testes fail to develop and no testosterone or Müllerian inhibiting factor are secreted so the male genital organs fail to develop while the female genital organs develop into the final genital organs (4,5). Clinically these patients are designated as XY pure gonadal dysgenesis or XY females.…”

Section: Pure Gonadal Dysgenesismentioning

confidence: 99%

Sex Chromosome and Chromatin Examination in Gynecology

Ge¹,

Liyu²,

Minyi³

et al. 1980

Gynecol Obstet Invest

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Sex chromosome and chromatin examinations with hormone determinations were done on 41 cases seen at the gynecologic clinic suspected of having sexual developmental abnormalities. 22 (53.7%) had genetic, gonadal or hormonal abnormalities, including ovarian dysgenesis 9 cases, superfemale 1 case, XY pure gonadal dysgenesis 4 cases, 3 of whom had already developed gonadal malignancy, pseudovaginal perineoscrotal hypospadias 1 case, androgen insensitivity syndrome 2 cases and congenital adrenal hyperplasia 3 cases. The values and limitations of sex chromosome and chromatin examinations as well as the prevention of gonadal malignancy are discussed.

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Section: Pure Gonadal Dysgenesismentioning

confidence: 99%