The aetiology and pathogenesis of ovine foot-rot

Egerton, J. R.; Roberts, D. S.; Parsonson, I. M.

doi:10.1016/0021-9975(69)90007-3

Cited by 178 publications

(55 citation statements)

References 5 publications

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“…However, not all sheep exposed to D. nodosus get footrot and fewer than half of cases progress to separation of the hoof horn (Wassink et al, 2010). Early histopathological observations of tissue sections from footrot lesions described little inflammatory response in areas with D. nodosus , but severe inflammation in response to invasion by F. necrophorum (Egerton et al, 1969). Infiltration by polymorphonuclear leucocytes and a dense population of filamentous bacteria, visually identified as F. necrophorum were observed in ID sections (Parsonson et al, 1967).…”

Section: Introductionmentioning

confidence: 99%

Differential expression of Toll-like receptors and inflammatory cytokines in ovine interdigital dermatitis and footrot

Davenport

Heawood

Sessford

et al. 2014

Veterinary Immunology and Immunopathology

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Footrot is a common inflammatory bacterial disease affecting the health and welfare of sheep worldwide. The pathogenesis of footrot is complex and multifactorial. The primary causal pathogen is the anaerobic bacterium Dichelobacter nodosus, with Fusobacterium necrophorum also shown to play a key role in disease. Since immune-mediated pathology is implicated, the aim of this research was to investigate the role of the host response in interdigital dermatitis (ID) and footrot. We compared the expression of Toll-like receptors (TLRs) and pro-inflammatory cytokines and the histological appearance of clinically normal in comparison to ID and footrot affected tissues. Severe ID and footrot were characterised by significantly increased transcript levels of pro-inflammatory cytokines TNFα and IL1β and the pattern recognition receptors TLR2 and TLR4 in the interdigital skin. This was reflected in the histopathological appearance, with ID and footrot presenting progressive chronic-active pododermatitis with a mixed lymphocytic and neutrophilic infiltration, gradually increasing from a mild form in clinically normal feet, to moderate in ID and to a focally severe form with frequent areas of purulence in footrot. Stimulation with F. necrophorum and/or D. nodosus extracts demonstrated that dermal fibroblasts, the resident cell type of the dermis, also contribute to the inflammatory response to footrot bacteria by increased expression of TNFα, IL1β and TLR2. Overall, ID and footrot lead to a local inflammatory response given that expression levels of TLRs and IL1β were dependent on the disease state of the foot not the animal.

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Section: Introductionmentioning

confidence: 99%

Differential expression of Toll-like receptors and inflammatory cytokines in ovine interdigital dermatitis and footrot

Davenport

Heawood

Sessford

et al. 2014

Veterinary Immunology and Immunopathology

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show abstract

“…Based on this, the authors concluded that F. necrophorum may be a secondary pathogen. This hypothesis was supported by the studies of Egerton et al (25), showing that necrotic lesions are caused by D. nodosus. The contrary was, however, reported by Hickford et al (50).…”

Section: Dichelobacter Nodosusmentioning

confidence: 53%

“…The authors isolated strains of D. nodosus and F. necrophorum from the epidermis of freshly infected tissue, but could not isolate F. necrophorum from the same area a few days later. Strains of F. necrophorum were, however, isolated from decayed tissue (25). Based on these results, the authors concluded that D. nodosus on its own is not the causative agent.…”

Section: Pathogensmentioning

confidence: 96%

“…In a later study, Egerton et al (25) isolated coccobacilli and diphtheroids from infected tissue, but only from surface areas. The authors isolated strains of D. nodosus and F. necrophorum from the epidermis of freshly infected tissue, but could not isolate F. necrophorum from the same area a few days later.…”

Section: Pathogensmentioning

confidence: 99%

“…Although several bacteria and yeast species have been isolated from claws and hoofs, the Gram-negative bacteria Dichelobacter nodosus and Fusobacterium necrophorum are always associated with necrotic lesions (63,88). Associated signs of infection are lameness and severe weight loss (25,96). If the disease is left untreated, the infection may spread to joints, bones and tendons.…”

Section: Introductionmentioning

confidence: 99%

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