2019
DOI: 10.31234/osf.io/5r6nz
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The aetiology of social deficits within mental health disorders: The role of the immune system and endogenous opioids

Abstract: The American National Institute for Mental Health (NIMH) has put out a set of research goals that include a long-term plan to identify more reliable endogenous explanations for a wide variety of mental health disorders (Insel, 2013). In response to this, we have identified a major symptom that underlies multiple mental health disorders – social bonding dysfunction. We suggest that endogenous opioid abnormalities can lead to altered social bonding, which is a symptom of various mental health disorders, includi… Show more

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Cited by 3 publications
(2 citation statements)
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References 107 publications
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“…Endogenous opioids (EOs) are expressed in the peripheral and central nervous system where they modulate pain, reward, aversion, reinforcement, social bonding, and neurotransmitter signalling including that of glutamate and dopamine [ 16 , 17 ]. During IRS activation, immunocytes produce and release EOs [ 18 ] and express µ (MOR) and κ (KOR) opioid receptors [ 19 ].…”
Section: Introductionmentioning
confidence: 99%
“…Endogenous opioids (EOs) are expressed in the peripheral and central nervous system where they modulate pain, reward, aversion, reinforcement, social bonding, and neurotransmitter signalling including that of glutamate and dopamine [ 16 , 17 ]. During IRS activation, immunocytes produce and release EOs [ 18 ] and express µ (MOR) and κ (KOR) opioid receptors [ 19 ].…”
Section: Introductionmentioning
confidence: 99%
“…Endogenous opioids (EOs) are expressed in the peripheral and central nervous system where they modulate pain, reward, aversion, reinforcement, social bonding, and neurotransmitter signaling including that of glutamate and dopamine (Charles et al, 2020;Corder et al, 2018). During IRS activation, immunocytes produce and release EOs (Plein and Rittner 2018) and express µ (MOR) and κ (KOR) opioid receptors (Li et al, 2009).…”
Section: Introductionmentioning
confidence: 99%