2016
DOI: 10.1002/smll.201600673
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The Age of Cortical Neural Networks Affects Their Interactions with Magnetic Nanoparticles

Abstract: Despite increasing use of nanotechnology in neuroscience, the characterization of interactions between magnetic nanoparticles (MNPs) and primary cortical neural networks remains underdeveloped. In particular, how the age of primary neural networks affects MNP uptake and endocytosis is critical when considering MNP-based therapies for age-related diseases. In this study, primary cortical neural networks are cultured up to 4 weeks and with CCL11/eotaxin, an age-inducing chemokine, to create aged neural networks.… Show more

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Cited by 21 publications
(24 citation statements)
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“…1-2. We also found that when we stimulated the neurons with 600 to >1000 pN of force daily (with a stronger magnet and/or increased MNP dosage), cell viability decreased significantly due to induced cytotoxicity 168 or there was cell displacement in the former. Reproduced with permission from the American Chemical Society.…”
Section: Appendix Bmentioning
confidence: 71%
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“…1-2. We also found that when we stimulated the neurons with 600 to >1000 pN of force daily (with a stronger magnet and/or increased MNP dosage), cell viability decreased significantly due to induced cytotoxicity 168 or there was cell displacement in the former. Reproduced with permission from the American Chemical Society.…”
Section: Appendix Bmentioning
confidence: 71%
“…80 However, magnetic-based techniques normally utilize MNPs in the 100-250 nm range which is known to be less cytotoxic than their smaller counterparts. 58 It is also welldocumented that the size of MNPs affects their renal clearance, supporting that it is a good parameter to optimize to minimize cytotoxicity; 286 168 This led to increased intracellular free iron ion concentration and cytotoxicity, highlighting the age-dependence of nano-therapeutics.…”
Section: Minimizing Cytotoxicity From Magnetic Nanoparticlesmentioning
confidence: 99%
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“…2b), which was also reported in other studies. 54 Thus, primary cortical neurons most-likely respond to cationic nanoparticle clusters.…”
Section: Resultsmentioning
confidence: 99%
“…To study a direct force impact on transport behavior of intracellular vesicles, we utilize chitosan-coated superparamagnetic nanoparticles (Chi-NP), which become internalized in neurons through cell intrinsic uptake mechanism such as endocytosis and phagocytosis. 23 Exposing Chi-NPs to engineered magnetic field gradients on chip allows us to modulate vesicle trafficking within sub-populations of lipid vesicles in the intracellular space.…”
Section: Introductionmentioning
confidence: 99%