The age of developing diabetes and FTO polymorphisms (rs9939609, rs1421085, and rs9930506)

Abstract

Introduction: Type 2 diabetes (T2DM) is a common complex metabolic disorder that has a strong genetic predisposition. Fat mass and obesity-associated protein (FTO) is one of the genes of interest to us. Hypomethylation of a CpG site in the FTO gene was significantly associated with the risk of T2DM. The aim of the study was to find the answer to the question of whether the polymorphism changes of the FTO gene in the pathogenesis of type 2 diabetes are comparable in young, middle aged, and elderly people. Material and methods: The study involved 282 consecutive patients with type 2 diabetes, who attended a primary healthcare clinic in Southern Poland. The study subjects were divided into three groups according to the age at which type 2 diabetes mellitus was diagnosed (> 40 years old, 40-60 years old, and > 60 years old). The genotyping of rs9939609, rs1421085, and rs9930506 FTO polymorphisms was conducted using TaqManPre-designed SNP Genotyping Assay. Results: No statistically significant difference was shown between the examined FTO polymorphism (rs9939609, rs1421085, and rs9930506) distribution between the subjects diagnosed with diabetes < 40 years , 40-60 years, and > 60 years old. Conclusions: There were no statistically significant relationships between the different analysed anthropometric and other parameters and distribution of examined FTO polymorphisms (rs9939609 , rs1421085, and rs9930506). The age of diabetes was not affect by the tested FTO polymorphisms (rs9939609 , rs1421085, and rs9930506).

Genetic Variants of HNF4A, WFS1, DUSP9, FTO, and ZFAND6 Genes Are Associated with Prediabetes Susceptibility and Inflammatory Markers in the Saudi Arabian Population

“…FTO located on 16q12.2 is substantially associated with elevated basal metabolic rate and T2DM [ 46 ]. Numerous FTO gene variants have been reported with an amplified contributory effect on T2DM and obesity [ 47 , 48 ]. However, our study showed that SNP rs1164284 had the most substantial susceptibility to prediabetes in the Arab population.…”

FTO Common Obesity SNPs Interact with Actionable Environmental Factors: Physical Activity, Sugar-Sweetened Beverages and Wine Consumption

“…Moreover, a significant association between FTO rs11642841 (correlated with FTO rs9939609) and total sugar intake was reported [ 57 ]. A potential mechanism related to the interaction of these four particular FTO SNPs with SSBs may be explained by their association to sugar metabolism and insulin resistance [ 58 , 59 ], although reports on the role of rs1421085 in glucose metabolism were inconclusive [ 60 , 61 ]. Our results reinforce previous findings, but more importantly, they complete a bigger picture of a potential intervention strategy to prevent the effect of SSB consumption by targeting guidelines in this genetic group predisposed to obesity, specifically in women.…”