The age-related association between serum creatinine and cardiorespiratory morbidity and mortality and fractures among adults with cerebral palsy

Whitney, Daniel G.; Hurvitz, Edward A.

doi:10.1016/j.advms.2023.07.001

Advances in Medical Sciences

2023

DOI: 10.1016/j.advms.2023.07.001

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The age-related association between serum creatinine and cardiorespiratory morbidity and mortality and fractures among adults with cerebral palsy

Daniel G. Whitney

Edward A. Hurvitz

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2024

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Potential use of salivary TNF-α as a vaccine-induced pain biomarker in people with cerebral palsy and communication disorders

Sabater-Gárriz,

Cerón,

Montoya

et al. 2024

PLoS ONE

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Background Pain in people with cerebral palsy (CP) has been classically underestimated and poorly treated, particularly in individuals with impaired communication skills. Objective To analyze changes in different salivary metabolites and pain behavior scales after a painful procedure in adults with CP and adults with typical development. Methods Salivary levels of sTNF-α, sIgA, Cortisol, FRAP, ADA and Alpha Amylase, as well as 3 observational pain scales (Wong-Baker, Non-Communicating Adults Pain Checklist and Facial Action Coding System) were assessed before and after an intramuscular injection in 30 Individuals with CP and 30 healthy controls. Video recording of face expression was performed during the procedure for offline analysis. Results Pain in subjects with CP was higher than in healthy controls after the intramuscular injection as displayed by observational scales. sTNF-α experienced a significant post-stimulus increase in both groups and that increase shows a tendency to correlate with the observational scales scores. Other biomarkers classically associated with stress (cortisol, Alpha Amylase) remain stable. Conclusion sTNF-α might be a promising pain indicator. Further research using controlled painful stimuli of greater intensity and pain self-reports, would be necessary to better understand its use as a pain biomarker.

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Potential use of salivary TNF-α as a vaccine-induced pain biomarker in people with cerebral palsy and communication disorders

Sabater-Gárriz,

Cerón,

Montoya

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

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The age-related association between serum creatinine and cardiorespiratory morbidity and mortality and fractures among adults with cerebral palsy

Cited by 1 publication

References 43 publications

Potential use of salivary TNF-α as a vaccine-induced pain biomarker in people with cerebral palsy and communication disorders

Potential use of salivary TNF-α as a vaccine-induced pain biomarker in people with cerebral palsy and communication disorders

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