The Ageing Kidney

McLachlan, M. S. F.

doi:10.1016/s0140-6736(78)91522-2

Cited by 153 publications

(70 citation statements)

References 34 publications

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“…For this reason, in the present study number of medullary pyramids was dissimilar to that of kidney of western people. However the 19 that the kidney mass increases with increasing age upto 35 years and gradually decreases along with the increase of age particularly after 40 years, which may be a reflection of senile changes of the kidney and this was also correlated with the findings reported by Maclachlan 12 . Renal mass increases from about 50 gm at birth to more than 400 gm during the third and forth decades 13 .…”

Section: Resultssupporting

confidence: 85%

“…Of the amount of blood going to each kidney, 90% or more is distributed to the cortical area 10 . Thus the exposure to circulating toxic substance, culminating in loss of renal cells is greater for the cortex than medulla [10][11][12] . Renal mass increases from about 50gm at birth to more than 400gm during the third and fourth decades 13 and it decreases approximately one fifth of it between fourth to eighth decade of life.…”

Section: Introductionmentioning

confidence: 99%

“…of the loss of substance. After the seventh decade, interstitial fibrosis becomes particularly pronounced in the medulla 12 .…”

Section: Introductionmentioning

confidence: 99%

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Medulla of kidney A Postmortem Grossmorphological Study in Bangladeshi People

Hassan¹,

Rahaman²,

Khalil³

et al. 2014

Bangladesh J Med Sci

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Background: In Bangladesh, prevalence of kidney diseases is increasing day by day and it was observed that renal medulla is affected less in earlier period of life but in late period it becomes affected more. Moreover renal mass changes with age which affecting the medullary mass and consequently the number of medullary pyramids. So the present study was carried out to evaluate anatomical features of medulla and to count the medullary pyramids with age related changes in the number of the pyramids in Bangladeshi people. Study type: Cross sectional analytical type of study. Place and period of study: Department of Anatomy, Mymensingh Medical College, Mymensingh, Bangladesh from January 2004 to June 2005. Materials and methods: A total of 70 fresh human kidneys of both sexes and sides were collected from the morgue of Mymensingh Medical College at postmortem. The selected cases were between 5 to 60 years of age. The samples were divided into 3 different age groups (A: 05-15 years, B: 16-35 years, C: 36- 60 years) to observe the variations in number of medullary pyramid of kidney in different age groups. Results: Among three groups, highly significant (<0.001) differences were found statistically in the number of medullary pyramid. Conclusion: There were changes in the number of medullary pyramid of kidney in different age groups. DOI: http://dx.doi.org/10.3329/bjms.v13i2.18299 Bangladesh Journal of Medical Science Vol.13(2) 2014 p.155-157

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Section: Resultssupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

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Medulla of kidney A Postmortem Grossmorphological Study in Bangladeshi People

Hassan¹,

Rahaman²,

Khalil³

et al. 2014

Bangladesh J Med Sci

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“…4 Studies have reported both increased volume in the functional glomeruli and decreased glomerular density in aging kidneys. [52][53][54][55] The pathological characteristics of aging kidneys include glomerular sclerosis, tubular atrophy and tubulointerstitial fibrosis. 51 In aging kidney glomerulus, hyaline mesangial matrix expansion results in the obliteration of the glomerular capillary loops 56,57 and is associated with capillary tuft collapse and intra-capsular fibrosis.…”

Section: Pathological Changes In Aged Kidneysmentioning

confidence: 99%

Pathophysiology of the aging kidney and therapeutic interventions

2012

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Kidneys are among the organs affected by the aging process. Aging kidneys are characterized by progressive scarring and measurable declines in renal function. Deficiencies in renal function are associated with mortality in all populations. Therefore, if the kidneys age at an accelerated rate relative to the other organs in a particular individual, then slowing or reversing the kidney aging process may be a therapeutically useful strategy. In this review, we will discuss the physiology and pathogenesis of kidney aging and analyze potential therapeutic strategies for halting the aging process in the kidneys.

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“…13 Renal mass increases from birth to third and fourth decades 14 and declines approximately a fifth between fourth and eighth decades of life. 15 Age is a biologic process the effect of which is the gradual loss of functioning cells that do not have the ability to divide even in those persons who are fortunate enough to be spared from disease related tissue changes. 14 This is supported by the report of Sultana 16 and Alam 17 that the values of gross morphological parameters reach to their highest level by the age of 20-25 years than remain unchanged for 30-35 years and finally become progressed accordingly, particularly after 40 years of age which may be a reflection of senile changes of kidney.…”

Section: Introductionmentioning

confidence: 99%